Type iii ifns in pteropid bats: differential expression patterns provide evidence for distinct roles in antiviral immunity
文献类型：期刊论文
| 作者 | Zhou, Peng1,2; Cowled, Chris1; Todd, Shawn1; Crameri, Gary1; Virtue, Elena R.1,3; Marsh, Glenn A.1; Klein, Reuben1; Shi, Zhengli2; Wang, Lin-Fa1,3; Baker, Michelle L.1,4 |
| 刊名 | Journal of immunology
 |
| 出版日期 | 2011-03-01 |
| 卷号 | 186期号:5页码:3138-3147 |
| ISSN号 | 0022-1767 |
| DOI | 10.4049/jimmunol.1003115 |
| 通讯作者 | Baker, michelle l.(michelle.baker@csiro.au) |
| 英文摘要 | Bats are known to harbor a number of emerging and re-emerging zoonotic viruses, many of which are highly pathogenic in other mammals but result in no clinical symptoms in bats. the ability of bats to coexist with viruses may be the result of rapid control of viral replication early in the immune response. ifns provide the first line of defense against viral infection in vertebrates. type iii ifns (ifn-lambda s) are a recently identified ifn family that share similar antiviral activities with type i ifns. to our knowledge, we demonstrate the first functional analysis of type iii ifns from any species of bat, with the investigation of two ifn-lambda genes from the pteropid bat, pteropus alecto. our results demonstrate that bat type iii ifn has similar antiviral activity to type i and iii ifns from other mammals. in addition, the two bat type iii ifns are differentially induced relative to each other and to type i ifns after treatment or transfection with synthetic dsrna. infection with the bat paramyxovirus, tioman virus, resulted in no upregulation of type i ifn production in bat splenocytes but was capable of inducing a type iii ifn response in three of the four bats tested. to our knowledge, this is the first report to describe the simultaneous suppression of type i ifn and induction of type iii ifn after virus infection. these results may have important implications for the role of type iii ifns in the ability of bats to coexist with viruses. the journal of immunology, 2011, 186: 3138-3147. |
| WOS关键词 | BLACK FLYING FOX ; FRUIT BATS ; INTERFERON GENES ; HENDRA VIRUS ; NIPAH VIRUS ; LAMBDA ; RECEPTOR ; INDUCTION ; INFECTION ; FAMILY |
| WOS研究方向 | Immunology |
| WOS类目 | Immunology |
| 语种 | 英语 |
| 出版者 | AMER ASSOC IMMUNOLOGISTS |
| WOS记录号 | WOS:000287356900052 |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2375858 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Baker, Michelle L. |
| 作者单位 | 1.Commonwealth Sci & Ind Res Org Livestock Ind, Australian Anim Hlth Lab, Geelong, Vic 3220, Australia 2.Chinese Acad Sci, State Key Lab Virol, Wuhan Inst Virol, Wuhan 430071, Peoples R China 3.Univ Melbourne, Dept Microbiol & Immunol, Parkville, Vic 3010, Australia 4.Univ New Mexico, Dept Biol, Ctr Evolutionary & Theoret Immunol, Albuquerque, NM 87131 USA |
| 推荐引用方式 GB/T 7714 | Zhou, Peng,Cowled, Chris,Todd, Shawn,et al. Type iii ifns in pteropid bats: differential expression patterns provide evidence for distinct roles in antiviral immunity[J]. Journal of immunology,2011,186(5):3138-3147. |
| APA | Zhou, Peng.,Cowled, Chris.,Todd, Shawn.,Crameri, Gary.,Virtue, Elena R..,...&Baker, Michelle L..(2011).Type iii ifns in pteropid bats: differential expression patterns provide evidence for distinct roles in antiviral immunity.Journal of immunology,186(5),3138-3147. |
| MLA | Zhou, Peng,et al."Type iii ifns in pteropid bats: differential expression patterns provide evidence for distinct roles in antiviral immunity".Journal of immunology 186.5(2011):3138-3147. |
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来源：武汉病毒研究所
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