Molecular characterisation of toll-like receptors in the black flying fox pteropus alecto
文献类型：期刊论文
| 作者 | Cowled, Christopher1; Baker, Michelle1,2; Tachedjian, Mary1; Zhou, Peng3; Bulach, Dieter1; Wang, Lin-Fa1,4 |
| 刊名 | Developmental and comparative immunology
 |
| 出版日期 | 2011 |
| 卷号 | 35期号:1页码:7-18 |
| ISSN号 | 0145-305X |
| 关键词 | Innate immunity Viral infection Toll-like receptor Chiroptera Pteropus alecto Fruit bat |
| DOI | 10.1016/j.dci.2010.07.006 |
| 通讯作者 | Baker, michelle(michelle.baker@csiro.au) |
| 英文摘要 | Bats are believed to be reservoir hosts for a number of emerging and re-emerging viruses, many of which are responsible for illness and mortality in humans, livestock and other animals. in other vertebrates, early responses to viral infection involve engagement of toll-like receptors (tlrs). which induce changes in gene expression collectively leading to an "antiviral state". in this study we report the cloning and bioinformatic analysis of a complete set of tlrs from the black flying fox pteropus alecto, and perform quantitative tissue expression analysis of the nucleic acid-sensing tlrs 3, 7, 8 and 9. full-length mrna transcripts from tlrs homologous to human tlrs 1-10 were sequenced, as well as a nearly intact tlr13 pseudogene that was spliced and polyadenylated. this prototype data can now be used to design functional studies of the bat innate immune system. crown copyright (c) 2010 published by elsevier ltd. all rights reserved. |
| WOS关键词 | DNA TRANSPOSON ACTIVITY ; FRUIT BATS ; PLACENTAL MAMMALS ; HENDRA VIRUS ; NIPAH VIRUS ; EVOLUTION ; TRANSMISSION ; RECOGNITION ; SEQUENCE ; PROTEIN |
| WOS研究方向 | Immunology ; Zoology |
| WOS类目 | Immunology ; Zoology |
| 语种 | 英语 |
| 出版者 | ELSEVIER SCI LTD |
| WOS记录号 | WOS:000285024400002 |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2375863 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Baker, Michelle |
| 作者单位 | 1.CSIRO Livestock Ind, Australian Anim Hlth Lab, Geelong, Vic 3220, Australia 2.Univ New Mexico, Dept Biol, Ctr Evolutionary & Theoret Immunol, Albuquerque, NM 87131 USA 3.Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, Wuhan, Peoples R China 4.Australian Biosecur Cooperat Res Ctr Emerging Inf, Geelong, Vic 3220, Australia |
| 推荐引用方式 GB/T 7714 | Cowled, Christopher,Baker, Michelle,Tachedjian, Mary,et al. Molecular characterisation of toll-like receptors in the black flying fox pteropus alecto[J]. Developmental and comparative immunology,2011,35(1):7-18. |
| APA | Cowled, Christopher,Baker, Michelle,Tachedjian, Mary,Zhou, Peng,Bulach, Dieter,&Wang, Lin-Fa.(2011).Molecular characterisation of toll-like receptors in the black flying fox pteropus alecto.Developmental and comparative immunology,35(1),7-18. |
| MLA | Cowled, Christopher,et al."Molecular characterisation of toll-like receptors in the black flying fox pteropus alecto".Developmental and comparative immunology 35.1(2011):7-18. |
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来源：武汉病毒研究所
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