Comprehensive characterization of interaction complexes of herpes simplex virus type 1 icp22, ul3, ul4, and ul20.5
文献类型：期刊论文
| 作者 | Xing, Junji1; Wang, Shuai1; Lin, Fusen1; Pan, Weiwei1; Hu, Chang-Deng2; Zheng, Chunfu1 |
| 刊名 | Journal of virology
 |
| 出版日期 | 2011-02-01 |
| 卷号 | 85期号:4页码:1881-1886 |
| ISSN号 | 0022-538X |
| DOI | 10.1128/jvi.01730-10 |
| 通讯作者 | Zheng, chunfu(zhengcf@wh.iov.cn) |
| 英文摘要 | It has been reported that herpes simplex virus type 1 ul3, ul4, and ul20.5 proteins are localized to small, dense nuclear bodies together with icp22 in infected cells. in the present study, we comprehensively characterized these interactions by subcellular colocalization, coimmunoprecipitation, and bimolecular fluorescence complementation assays. for the first time, it was demonstrated that both ul3 and ul20.5 are targeted to small, dense nuclear bodies by a direct interaction with icp22, whereas ul4 colocalizes with icp22 through its interaction with ul3 but not ul20.5 or icp22. there was no detectable interaction between ul3 and ul20.5. |
| WOS关键词 | RNA-POLYMERASE-II ; BIMOLECULAR FLUORESCENCE COMPLEMENTATION ; REGULATORY PROTEIN ICP22 ; LIVING CELLS ; EXPRESSION ; IDENTIFICATION ; VISUALIZATION ; REPLICATION ; GENES ; PHOSPHATASE |
| WOS研究方向 | Virology |
| WOS类目 | Virology |
| 语种 | 英语 |
| WOS记录号 | WOS:000286420900043 |
| 出版者 | AMER SOC MICROBIOLOGY |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2375864 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Zheng, Chunfu |
| 作者单位 | 1.Chinese Acad Sci, Wuhan Inst Virol, Mol Virol & Viral Immunol Res Grp, State Key Lab Virol, Wuhan 430070, Peoples R China 2.Purdue Univ, Dept Med Chem & Mol Pharmacol, W Lafayette, IN 47907 USA |
| 推荐引用方式 GB/T 7714 | Xing, Junji,Wang, Shuai,Lin, Fusen,et al. Comprehensive characterization of interaction complexes of herpes simplex virus type 1 icp22, ul3, ul4, and ul20.5[J]. Journal of virology,2011,85(4):1881-1886. |
| APA | Xing, Junji,Wang, Shuai,Lin, Fusen,Pan, Weiwei,Hu, Chang-Deng,&Zheng, Chunfu.(2011).Comprehensive characterization of interaction complexes of herpes simplex virus type 1 icp22, ul3, ul4, and ul20.5.Journal of virology,85(4),1881-1886. |
| MLA | Xing, Junji,et al."Comprehensive characterization of interaction complexes of herpes simplex virus type 1 icp22, ul3, ul4, and ul20.5".Journal of virology 85.4(2011):1881-1886. |
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来源：武汉病毒研究所
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