Mitochondrial electron transport chain complex iii is required for antimycin a to inhibit autophagy
文献类型：期刊论文
| 作者 | Ma, Xiuquan2; Jin, Mingzhi2; Cai, Yu2; Xia, Hongguang2; Long, Kai2; Liu, Junli2; Yu, Qiang1; Yuan, Junying2,3 |
| 刊名 | Chemistry & biology
 |
| 出版日期 | 2011-11-23 |
| 卷号 | 18期号:11页码:1474-1481 |
| ISSN号 | 1074-5521 |
| DOI | 10.1016/j.chembiol.2011.08.009 |
| 通讯作者 | Yu, qiang(qyu@sibs.ac.cn) |
| 英文摘要 | Autophagy is a cellular lysosome-dependent catabolic mechanism mediating the turnover of intracellular organelles and long-lived proteins. we show that antimycin a, a known inhibitor of metc complex iii, can inhibit autophagy. a structural and functional study shows that four close analogs of antimycin a that have no effect on mitochondria inhibition also do not inhibit autophagy, whereas myxothiazol, another metc complex iii inhibitor with unrelated structure to antimycin a, inhibits autophagy. additionally, antimycin a and myxothiazol cannot inhibit autophagy in mtdna-depleted h4 and mtdna-depleted he la cells. these data suggest that antimycin a inhibits autophagy through its inhibitory activity on metc complex iii. our data suggest that metc complex iii may have a role in mediating autophagy induction. |
| WOS关键词 | ENDOPLASMIC-RETICULUM ; REACTIVE OXYGEN ; SACCHAROMYCES-CEREVISIAE ; CELL-DEATH ; GOLGI ; MEMBRANES ; APOPTOSIS ; REVEALS ; DISEASE ; ADIPOGENESIS |
| WOS研究方向 | Biochemistry & Molecular Biology |
| WOS类目 | Biochemistry & Molecular Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000297603600019 |
| 出版者 | CELL PRESS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2375869 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Yu, Qiang |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Dept Pharmacol, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Bioorgan & Nat Prod Chem, Shanghai 200032, Peoples R China 3.Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA |
| 推荐引用方式 GB/T 7714 | Ma, Xiuquan,Jin, Mingzhi,Cai, Yu,et al. Mitochondrial electron transport chain complex iii is required for antimycin a to inhibit autophagy[J]. Chemistry & biology,2011,18(11):1474-1481. |
| APA | Ma, Xiuquan.,Jin, Mingzhi.,Cai, Yu.,Xia, Hongguang.,Long, Kai.,...&Yuan, Junying.(2011).Mitochondrial electron transport chain complex iii is required for antimycin a to inhibit autophagy.Chemistry & biology,18(11),1474-1481. |
| MLA | Ma, Xiuquan,et al."Mitochondrial electron transport chain complex iii is required for antimycin a to inhibit autophagy".Chemistry & biology 18.11(2011):1474-1481. |
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来源：武汉病毒研究所
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