Effects of microtubule modulators on hiv-1 infection of transformed and resting cd4 t cells
文献类型：期刊论文
| 作者 | Yoder, Alyson1; Guo, Jia1; Yu, Dongyang1; Cui, Zongqiang1,2; Zhang, Xian-En2; Wu, Yuntao1 |
| 刊名 | Journal of virology
 |
| 出版日期 | 2011-03-01 |
| 卷号 | 85期号:6页码:3020-3024 |
| ISSN号 | 0022-538X |
| DOI | 10.1128/jvi.02462-10 |
| 通讯作者 | Wu, yuntao(ywu8@gmu.edu) |
| 英文摘要 | Previous studies have observed fluorescently labeled hiv particles tracking along microtubule networks for nuclear localization. to provide direct evidence for the involvement of microtubules in early steps of hiv infection of human cd4 t cells, we used multiple microtubule modulators such as paclitaxel (originally called taxol; 1 mu m), vinblastine (1 and 10 mu m), colchicine (10 and 100 mu m), and nocodazole (10 and 100 mu m) to disturb microtubule networks in transformed and resting cd4 t cells. although these drugs disrupted microtubule integrity, almost no inhibition of hiv-1 infection was observed. our results do not appear to support an essential role for microtubules in the initiation of hiv infection of cd4 t cells. |
| WOS关键词 | HUMAN-IMMUNODEFICIENCY-VIRUS ; SIGNAL-TRANSDUCTION ; LIVING CELLS ; TYPE-1 HIV-1 ; NEF PROTEIN ; ACTIN ; CYTOSKELETON ; TUBULIN ; VINBLASTINE ; RECEPTOR |
| WOS研究方向 | Virology |
| WOS类目 | Virology |
| 语种 | 英语 |
| WOS记录号 | WOS:000288386500053 |
| 出版者 | AMER SOC MICROBIOLOGY |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2375915 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Wu, Yuntao |
| 作者单位 | 1.George Mason Univ, Natl Ctr Biodef & Infect Dis, Dept Mol & Microbiol, Manassas, VA 20110 USA 2.Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, Wuhan 430071, Hubei, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yoder, Alyson,Guo, Jia,Yu, Dongyang,et al. Effects of microtubule modulators on hiv-1 infection of transformed and resting cd4 t cells[J]. Journal of virology,2011,85(6):3020-3024. |
| APA | Yoder, Alyson,Guo, Jia,Yu, Dongyang,Cui, Zongqiang,Zhang, Xian-En,&Wu, Yuntao.(2011).Effects of microtubule modulators on hiv-1 infection of transformed and resting cd4 t cells.Journal of virology,85(6),3020-3024. |
| MLA | Yoder, Alyson,et al."Effects of microtubule modulators on hiv-1 infection of transformed and resting cd4 t cells".Journal of virology 85.6(2011):3020-3024. |
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来源：武汉病毒研究所
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