中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Effects of microtubule modulators on hiv-1 infection of transformed and resting cd4 t cells

文献类型:期刊论文

作者Yoder, Alyson1; Guo, Jia1; Yu, Dongyang1; Cui, Zongqiang1,2; Zhang, Xian-En2; Wu, Yuntao1
刊名Journal of virology
出版日期2011-03-01
卷号85期号:6页码:3020-3024
ISSN号0022-538X
DOI10.1128/jvi.02462-10
通讯作者Wu, yuntao(ywu8@gmu.edu)
英文摘要Previous studies have observed fluorescently labeled hiv particles tracking along microtubule networks for nuclear localization. to provide direct evidence for the involvement of microtubules in early steps of hiv infection of human cd4 t cells, we used multiple microtubule modulators such as paclitaxel (originally called taxol; 1 mu m), vinblastine (1 and 10 mu m), colchicine (10 and 100 mu m), and nocodazole (10 and 100 mu m) to disturb microtubule networks in transformed and resting cd4 t cells. although these drugs disrupted microtubule integrity, almost no inhibition of hiv-1 infection was observed. our results do not appear to support an essential role for microtubules in the initiation of hiv infection of cd4 t cells.
WOS关键词HUMAN-IMMUNODEFICIENCY-VIRUS ; SIGNAL-TRANSDUCTION ; LIVING CELLS ; TYPE-1 HIV-1 ; NEF PROTEIN ; ACTIN ; CYTOSKELETON ; TUBULIN ; VINBLASTINE ; RECEPTOR
WOS研究方向Virology
WOS类目Virology
语种英语
WOS记录号WOS:000288386500053
出版者AMER SOC MICROBIOLOGY
URI标识http://www.irgrid.ac.cn/handle/1471x/2375915
专题武汉病毒研究所
通讯作者Wu, Yuntao
作者单位1.George Mason Univ, Natl Ctr Biodef & Infect Dis, Dept Mol & Microbiol, Manassas, VA 20110 USA
2.Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, Wuhan 430071, Hubei, Peoples R China
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GB/T 7714
Yoder, Alyson,Guo, Jia,Yu, Dongyang,et al. Effects of microtubule modulators on hiv-1 infection of transformed and resting cd4 t cells[J]. Journal of virology,2011,85(6):3020-3024.
APA Yoder, Alyson,Guo, Jia,Yu, Dongyang,Cui, Zongqiang,Zhang, Xian-En,&Wu, Yuntao.(2011).Effects of microtubule modulators on hiv-1 infection of transformed and resting cd4 t cells.Journal of virology,85(6),3020-3024.
MLA Yoder, Alyson,et al."Effects of microtubule modulators on hiv-1 infection of transformed and resting cd4 t cells".Journal of virology 85.6(2011):3020-3024.

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来源:武汉病毒研究所

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