Poliovirus 2a(pro) induces the nucleic translocation of poliovirus 3cd and 3c' proteins
文献类型：期刊论文
| 作者 | Tian, Wenwu1,2; Cui, Zongqiang1; Zhang, Zhiping1; Wei, Hongping1; Zhang, XianEn1 |
| 刊名 | Acta biochimica et biophysica sinica
 |
| 出版日期 | 2011 |
| 卷号 | 43期号:1页码:38-44 |
| 关键词 | Poliovirus 2a(pro) 3cd 3c' Nuclear localization |
| ISSN号 | 1672-9145 |
| DOI | 10.1093/abbs/gmq112 |
| 通讯作者 | Cui, zongqiang(czq@wh.iov.cn) |
| 英文摘要 | Poliovirus genomic rna replication, protein translation, and virion assembly are performed in the cytoplasm of host cells. however, this does not mean that there is no relationship between poliovirus infection and the cellular nucleus. in this study, recombinant fluorescence-tagged poliovirus 3cd and 3c' proteins were shown to be expressed mainly in the cytoplasm of vero cells in the absence of other viral proteins. however, upon poliovirus infection, many of these proteins redistributed to the nucleus, as well as to the cytoplasm. a series of transfection experiments revealed that the poliovirus 2a(pro) was responsible for the same redistribution of 3cd and 3c' proteins to the nucleus. furthermore, a mutant 2a(pro) protein lacking protease activity abrogated this effect. the poliovirus 2a(pro) protein was also found to co-localize with the nup153 protein, a component of the nuclear pore complexes on the nuclear envelope. these data provide further evidence that there are intrinsic interactions between poliovirus proteins and the cell nucleus, despite that many processes in the poliovirus replication cycle occur in the cytoplasm. |
| WOS关键词 | ENCODED PROTEASE 3C(PRO) ; HOST-CELL TRANSCRIPTION ; TATA-BINDING PROTEIN ; POLY(A)-BINDING PROTEIN ; INFECTED-CELLS ; MESSENGER-RNA ; IN-VITRO ; EFFICIENT CLEAVAGE ; GENE-EXPRESSION ; PORE COMPLEXES |
| WOS研究方向 | Biochemistry & Molecular Biology ; Biophysics |
| WOS类目 | Biochemistry & Molecular Biology ; Biophysics |
| 语种 | 英语 |
| WOS记录号 | WOS:000285628600006 |
| 出版者 | OXFORD UNIV PRESS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2375935 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Cui, Zongqiang |
| 作者单位 | 1.Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, Wuhan 430071, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tian, Wenwu,Cui, Zongqiang,Zhang, Zhiping,et al. Poliovirus 2a(pro) induces the nucleic translocation of poliovirus 3cd and 3c' proteins[J]. Acta biochimica et biophysica sinica,2011,43(1):38-44. |
| APA | Tian, Wenwu,Cui, Zongqiang,Zhang, Zhiping,Wei, Hongping,&Zhang, XianEn.(2011).Poliovirus 2a(pro) induces the nucleic translocation of poliovirus 3cd and 3c' proteins.Acta biochimica et biophysica sinica,43(1),38-44. |
| MLA | Tian, Wenwu,et al."Poliovirus 2a(pro) induces the nucleic translocation of poliovirus 3cd and 3c' proteins".Acta biochimica et biophysica sinica 43.1(2011):38-44. |
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来源：武汉病毒研究所
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