Type iii ifn receptor expression and functional characterisation in the pteropid bat, pteropus alecto
文献类型：期刊论文
| 作者 | Zhou, Peng1,2; Cowled, Chris1; Marsh, Glenn A.1; Shi, Zhengli2; Wang, Lin-Fa1,3; Baker, Michelle L.1,4 |
| 刊名 | Plos one
 |
| 出版日期 | 2011-09-27 |
| 卷号 | 6期号:9页码:8 |
| ISSN号 | 1932-6203 |
| DOI | 10.1371/journal.pone.0025385 |
| 通讯作者 | Zhou, peng() |
| 英文摘要 | Bats are rich reservoir hosts for a variety of viruses, many of which are capable of spillover to other susceptible mammals with lethal consequences. the ability of bats to remain asymptomatic to viral infection may be due to the rapid control of viral replication very early in the immune response through innate antiviral mechanisms. type i and iii interferons (ifns) represent the first line of defence against viral infection in mammals, with both families of ifns present in pteropid bats. to obtain further insight into the type iii ifn system in bats, we describe the characterization of the type iii ifn receptor (ifn lambda r) in the black flying fox, p. alecto with the characterization of ifn lambda r1 and il10r2 genes that make up the type iii ifn receptor complex. the bat ifn lambda r complex has a wide tissue distribution and at the cellular level, both epithelial and immune cells are responsive to ifn-lambda treatment. furthermore, we demonstrate that the bat ifn lambda r1 chain acts as a functional receptor. to our knowledge, this report represents the first description of an ifn receptor in any species of bat. the responsiveness of bat cells to ifn-lambda support a role for the type iii ifn system by epithelial and immune cells in bats. |
| WOS关键词 | IL-10 RECEPTOR-2 ; CYTOKINE ; INTERLEUKIN-22 ; INTERFERONS ; ALIGNMENT ; IMMUNITY ; COMPLEX ; FAMILY ; CELLS ; CHAIN |
| WOS研究方向 | Science & Technology - Other Topics |
| WOS类目 | Multidisciplinary Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000295933700029 |
| 出版者 | PUBLIC LIBRARY SCIENCE |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2375937 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Zhou, Peng |
| 作者单位 | 1.CSIRO Livestock Ind, Australian Anim Hlth Lab, Geelong, Vic, Australia 2.Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, Wuhan, Peoples R China 3.Univ Melbourne, Dept Microbiol & Immunol, Parkville, Vic 3052, Australia 4.Univ New Mexico, Dept Biol, Ctr Evolutionary & Theoret Immunol, Albuquerque, NM 87131 USA |
| 推荐引用方式 GB/T 7714 | Zhou, Peng,Cowled, Chris,Marsh, Glenn A.,et al. Type iii ifn receptor expression and functional characterisation in the pteropid bat, pteropus alecto[J]. Plos one,2011,6(9):8. |
| APA | Zhou, Peng,Cowled, Chris,Marsh, Glenn A.,Shi, Zhengli,Wang, Lin-Fa,&Baker, Michelle L..(2011).Type iii ifn receptor expression and functional characterisation in the pteropid bat, pteropus alecto.Plos one,6(9),8. |
| MLA | Zhou, Peng,et al."Type iii ifn receptor expression and functional characterisation in the pteropid bat, pteropus alecto".Plos one 6.9(2011):8. |
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来源：武汉病毒研究所
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