Ns deletions convert the 2009-h1n1 pandemic virus into a live attenuated vaccine
文献类型：期刊论文
| 作者 | Zhou, Bin1,2; Li, Yan1,3; Belser, Jessica A.4; Pearce, Melissa B.4; Schmolke, Mirco5; Subba, Anju1; Shi, Zhengli3; Zaki, Sherif R.6; Blau, Dianna M.6; Garcia-Sastre, Adolfo5,7,8 |
| 刊名 | Influenza and other respiratory viruses
 |
| 出版日期 | 2011-05-01 |
| 卷号 | 5页码:388-391 |
| 关键词 | H1n1 Live attenuated Ns Pandemic Vaccine |
| ISSN号 | 1750-2640 |
| 通讯作者 | Zhou, bin() |
| 英文摘要 | Although vaccines against influenza a virus are the most effective method by which to combat infection, it is clear that their production needs to be accelerated and their efficacy improved. a panel of recombinant live attenuated human influenza a vaccines (laivs), including ns1-73, ns1-126, nsd5, were generated by rationally engineering mutations directly into the genome of a pandemic-h1n1 virus. the vaccine potential of each laiv was determined through analysis of attenuation, immunogenicity, and their ability to protect mice and ferrets. the data indicate that the novel nsd5-laiv was ideally attenuated and elicited strong protective immunity. this study also shows that attenuating mutations can be rapidly engineered into the genomes of emerging/circulating influenza a viruses in order to produce laivs. |
| WOS关键词 | INFLUENZA-A VIRUS ; ADAPTIVE IMMUNITY ; PROTEIN ; RESPONSES ; INNATE ; SYSTEM ; CELLS |
| WOS研究方向 | Infectious Diseases ; Virology |
| WOS类目 | Infectious Diseases ; Virology |
| 语种 | 英语 |
| WOS记录号 | WOS:000289296200127 |
| 出版者 | WILEY-BLACKWELL |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2375943 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Zhou, Bin |
| 作者单位 | 1.SUNY Albany, Sch Publ Hlth, New York State Dept Hlth, Wadsworth Ctr, Albany, NY 12222 USA 2.SUNY Albany, Sch Publ Hlth, Dept Biomed Sci, Albany, NY USA 3.Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, Wuhan, Peoples R China 4.Ctr Dis Control & Prevent, Immunol & Pathogenesis Branch, Influenza Div, NCIRD, Atlanta, GA USA 5.Mt Sinai Sch Med, Dept Microbiol, New York, NY USA 6.Ctr Dis Control & Prevent, Infect Dis Pathol Branch, Atlanta, GA USA 7.Mt Sinai Sch Med, Inst Global Hlth & Emerging Pathogens, New York, NY USA 8.Mt Sinai Sch Med, Dept Med, Div Infect Dis, New York, NY USA |
| 推荐引用方式 GB/T 7714 | Zhou, Bin,Li, Yan,Belser, Jessica A.,et al. Ns deletions convert the 2009-h1n1 pandemic virus into a live attenuated vaccine[J]. Influenza and other respiratory viruses,2011,5:388-391. |
| APA | Zhou, Bin.,Li, Yan.,Belser, Jessica A..,Pearce, Melissa B..,Schmolke, Mirco.,...&Wentworth, David E..(2011).Ns deletions convert the 2009-h1n1 pandemic virus into a live attenuated vaccine.Influenza and other respiratory viruses,5,388-391. |
| MLA | Zhou, Bin,et al."Ns deletions convert the 2009-h1n1 pandemic virus into a live attenuated vaccine".Influenza and other respiratory viruses 5(2011):388-391. |
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来源：武汉病毒研究所
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