Characterization of molecular determinants for nucleocytoplasmic shuttling of prv ul54
文献类型：期刊论文
| 作者 | Li, Meili1; Wang, Shuai2; Cai, Mingsheng1; Guo, Hong1; Zheng, Chunfu1 |
| 刊名 | Virology
 |
| 出版日期 | 2011-09-01 |
| 卷号 | 417期号:2页码:385-393 |
| 关键词 | Prv ul54 Nucleocytoplasmic shuttling Importin Tap/nxf1 Ran-gtp |
| ISSN号 | 0042-6822 |
| DOI | 10.1016/j.virol.2011.06.004 |
| 通讯作者 | Zheng, chunfu(zheng.alan@hotmail.com) |
| 英文摘要 | The pseudorabies virus (prv) early protein ul54 is a homologue of the herpes simplex virus 1 (hsv-1) immediate-early protein icp27, which is a multifunctional protein and essential for hsv-1 infection. to determine if ul54 might shuttle between the nucleus and cytoplasm, as has been shown for its homologues in human herpesviruses, the molecular determinants for its nucleocytoplasmic shuttling were investigated. heterokaryon assays demonstrated that ul54 was a nucleocytoplasmic shuttling protein and this property could not be blocked by leptomycin b, an inhibitor of chromosome region maintenance 1 (crm1). however, tap/nxf1 promoted the nuclear export of ul54 and interacted with ul54, suggesting that ul54 shuttles between the nucleus and the cytoplasm via a tap/nxf1, but not crm1, dependent nuclear export pathway. furthermore, ul54 was demonstrated to target to the nucleus through a classic ran-, importin beta 1- and alpha 5-dependent nuclear import mechanism. (c) 2011 elsevier inc. all rights reserved. |
| WOS关键词 | HERPES-SIMPLEX-VIRUS ; MESSENGER-RNA EXPORT ; NUCLEAR-PORE COMPLEX ; ACTIVATED PROTEIN-KINASE ; INFECTED CELL PROTEIN-27 ; NF-KAPPA-B ; PSEUDORABIES VIRUS ; HUMAN CYTOMEGALOVIRUS ; REGULATORY PROTEIN ; IMPORTIN-ALPHA |
| WOS研究方向 | Virology |
| WOS类目 | Virology |
| 语种 | 英语 |
| WOS记录号 | WOS:000294578600018 |
| 出版者 | ACADEMIC PRESS INC ELSEVIER SCIENCE |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2375950 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Zheng, Chunfu |
| 作者单位 | 1.Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, Wuhan 430071, Peoples R China 2.Chinese Acad Sci, Wuhan Inst Virol, Key Lab Agr & Environm Microbiol, Wuhan 430071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Meili,Wang, Shuai,Cai, Mingsheng,et al. Characterization of molecular determinants for nucleocytoplasmic shuttling of prv ul54[J]. Virology,2011,417(2):385-393. |
| APA | Li, Meili,Wang, Shuai,Cai, Mingsheng,Guo, Hong,&Zheng, Chunfu.(2011).Characterization of molecular determinants for nucleocytoplasmic shuttling of prv ul54.Virology,417(2),385-393. |
| MLA | Li, Meili,et al."Characterization of molecular determinants for nucleocytoplasmic shuttling of prv ul54".Virology 417.2(2011):385-393. |
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来源：武汉病毒研究所
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