Comparison of humoral immune responses to epstein-barr virus and kaposi's sarcoma-associated herpesvirus using a viral proteome microarray
文献类型：期刊论文
| 作者 | Zheng, Dasheng1,5; Wan, Jun4; Cho, Yong Gu1; Wang, Leyao1; Chiou, Chuang-Jiun1; Pai, Shweta1; Woodard, Crystal3; Zhu, Jian3; Liao, Gangling1; Martinez-Maza, Otoniel6 |
| 刊名 | Journal of infectious diseases
 |
| 出版日期 | 2011-12-01 |
| 卷号 | 204期号:11页码:1683-1691 |
| ISSN号 | 0022-1899 |
| DOI | 10.1093/infdis/jir645 |
| 通讯作者 | Hayward, s. diane(dhayward@jhmi.edu) |
| 英文摘要 | Background. epstein-barr virus (ebv) is a ubiquitous herpesvirus, and kaposi's sarcoma-associated herpesvirus (kshv) has a restricted seroprevalence. both viruses are associated with malignancies that have an increased frequency in individuals who are coinfected with human immunodeficiency virus type 1 (hiv-1). methods. to obtain an overview of humoral immune responses to these viruses, we generated a protein array that displayed 174 ebv and kshv polypeptides purified from yeast. antibody responses to ebv and kshv were examined in plasma from healthy volunteers and patients with b cell lymphoma or with aids-related kaposi's sarcoma or lymphoma. results. in addition to the commonly studied antigens, igg responses were frequently detected to the tegument proteins kshv orf38 and ebv bbrf and bglf2 and bnrf1 and to the ebv early lytic proteins brrf1 and borf2. the ebv vil-10 protein was particularly well recognized by plasma iga. the most intense igg responses to ebv antigens occurred in hiv-1-positive patients. no clear correlation was observed between viral dna load in plasma and antibody profile. conclusions. the protein array provided a sensitive platform for global screening; identified new, frequently recognized viral antigens; and revealed a broader humoral response to ebv compared with kshv in the same patients. |
| WOS关键词 | NASOPHARYNGEAL CARCINOMA ; HUMAN-HERPESVIRUS-8 SEROPREVALENCE ; TERMINAL DIFFERENTIATION ; GENE-TRANSCRIPTION ; PRIMARY INFECTION ; SEROLOGIC ASSAYS ; BLOOD-DONORS ; RISK-FACTORS ; LATENT ; CELLS |
| WOS研究方向 | Immunology ; Infectious Diseases ; Microbiology |
| WOS类目 | Immunology ; Infectious Diseases ; Microbiology |
| 语种 | 英语 |
| WOS记录号 | WOS:000296297900007 |
| 出版者 | OXFORD UNIV PRESS INC |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2375951 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Hayward, S. Diane |
| 作者单位 | 1.Johns Hopkins Univ, Sidney Kimmel Canc Ctr, Dept Oncol, Johns Hopkins Sch Med, Baltimore, MD 21287 USA 2.Johns Hopkins Sch Med, Viral Oncol Program, Baltimore, MD USA 3.Johns Hopkins Sch Med, Dept Pharmacol, Baltimore, MD USA 4.Johns Hopkins Sch Med, Dept Ophthalmol, Baltimore, MD USA 5.Chinese Acad Sci, Wuhan Inst Virol, Beijing 100864, Peoples R China 6.Univ Calif Los Angeles, David Geffen Sch Med, UCLA AIDS Inst, Dept Microbiol Immunol & Mol Genet, Los Angeles, CA 90095 USA |
| 推荐引用方式 GB/T 7714 | Zheng, Dasheng,Wan, Jun,Cho, Yong Gu,et al. Comparison of humoral immune responses to epstein-barr virus and kaposi's sarcoma-associated herpesvirus using a viral proteome microarray[J]. Journal of infectious diseases,2011,204(11):1683-1691. |
| APA | Zheng, Dasheng.,Wan, Jun.,Cho, Yong Gu.,Wang, Leyao.,Chiou, Chuang-Jiun.,...&Hayward, S. Diane.(2011).Comparison of humoral immune responses to epstein-barr virus and kaposi's sarcoma-associated herpesvirus using a viral proteome microarray.Journal of infectious diseases,204(11),1683-1691. |
| MLA | Zheng, Dasheng,et al."Comparison of humoral immune responses to epstein-barr virus and kaposi's sarcoma-associated herpesvirus using a viral proteome microarray".Journal of infectious diseases 204.11(2011):1683-1691. |
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来源：武汉病毒研究所
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