Fe-56 ion irradiation induced apoptosis through nrf2 pathway in mouse testis
文献类型：期刊论文
| 作者 | Zhao, Qiuyue1,3,4,5; Mao, Aihong1,2,3,4,5; Yan, Jiawei1,3,4,5; Si, Jing1,3,4; Zhou, Rong1,3,4; Gan, Lu1,3,4; Liu, Yang1,3,4; Zhang, Hong1,3,4 |
| 刊名 | Life sciences
 |
| 出版日期 | 2016-07-15 |
| 卷号 | 157页码:32-37 |
| 关键词 | Fe-56 ion irradiation Nrf2 Apoptosis Testis |
| ISSN号 | 0024-3205 |
| DOI | 10.1016/j.lfs.2016.05.043 |
| 通讯作者 | Zhang, hong(zhangh@impcas.ac.cn) |
| 英文摘要 | The phenomenon has raised the concerns about the safety of an extended manned mission into deep space due to the high potential for exposure to high-let radiation during space missions. heavy ions such as fe-56 are main radiation sources in deep space, which could pose a significant hazard to space flight crews during and after missions. since the testis is a radiosensitive organ, which may be susceptible to space radiation-induced changes. in this study, we investigated the effect and potential mechanisms of fe-56 irradiation on mouse testis. pathological characteristics were measured following whole-body irradiation with 0.5 and 1 gy fe-56 irradiation. flow cytometry and terminal dutp nick end-labeling (tunel) were performed to detect apoptotic cells. western blot was applied to identify potential biomarkers. immunofluorescence was used to investigate protein localization. we found that pathologic changes and apoptosis cells were significantly higher in 1 gy group than those in 0 gy groups. in addition, protein expression and localization studies confirmed nrf2 was involved in this acute injury. nrf2 and its target genes ho-1 and nqo1 were up-regulated in the irradiated testis in a dose-dependent manner. nrf2 may be useful molecular markers in radiation-induced cellular responses and is important for detecting abnormal spermatogenesis following exposure to space radiation. (c) 2016 elsevier inc. all rights reserved. |
| WOS关键词 | PUBERTAL MICE TESTES ; RADIATION ; CELLS ; EXPOSURE ; MODULATION ; EXPRESSION ; PARTICLES ; PROTEOME ; DAMAGE ; SPERM |
| WOS研究方向 | Research & Experimental Medicine ; Pharmacology & Pharmacy |
| WOS类目 | Medicine, Research & Experimental ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000383520300005 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2376002 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Zhang, Hong |
| 作者单位 | 1.Chinese Acad Sci, Inst Modern Phys, Lanzhou 730000, Peoples R China 2.Inst Gansu Med Sci Res, Lanzhou 730050, Peoples R China 3.Chinese Acad Sci, Key Lab Heavy Ion Radiat Med, Lanzhou 730000, Peoples R China 4.Key Lab Heavy Ion Radiat Med Gansu Prov, Lanzhou 730000, Peoples R China 5.Univ Chinese Acad Sci, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, Qiuyue,Mao, Aihong,Yan, Jiawei,et al. Fe-56 ion irradiation induced apoptosis through nrf2 pathway in mouse testis[J]. Life sciences,2016,157:32-37. |
| APA | Zhao, Qiuyue.,Mao, Aihong.,Yan, Jiawei.,Si, Jing.,Zhou, Rong.,...&Zhang, Hong.(2016).Fe-56 ion irradiation induced apoptosis through nrf2 pathway in mouse testis.Life sciences,157,32-37. |
| MLA | Zhao, Qiuyue,et al."Fe-56 ion irradiation induced apoptosis through nrf2 pathway in mouse testis".Life sciences 157(2016):32-37. |
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来源：中国科学院大学
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