Acid-activatable versatile micelleplexes for pd-l1 blockade enhanced cancer photodynamic immunotherapy
文献类型：期刊论文
| 作者 | Wang, Dangge1,2,3; Wang, Tingting1,2,3; Liu, Jianping1,2; Yu, Haijun1,2; Jiao, Shi4; Feng, Bing1,2,3; Zhou, Fangyuan1,2; Fu, Yuanlei1,2; Yin, Qi1,2; Zhang, Pengcheng1,2 |
| 刊名 | Nano letters
 |
| 出版日期 | 2016-09-01 |
| 卷号 | 16期号:9页码:5503-5513 |
| 关键词 | Micelleplexes Acid-activatable Photodynamic therapy Cancer immunotherapy Rna interference |
| ISSN号 | 1530-6984 |
| DOI | 10.1021/acs.nanolett.6b01994 |
| 通讯作者 | Yu, haijun(hjyu@simm.ac.cn) ; Li, yaping(ypli@simm.ac.cn) |
| 英文摘要 | Photodynamic therapy (pdt) has emerged as a promising clinical modality for cancer therapy due to its ability to initiate an antitumor immune response. however, pdt-mediated cancer immunotherapy is severely impaired by tumor-cell immunosuppression of host t cell antitumor activity through the programmed cell death 1 ligand (pd-l1) and programmed cell death receptor 1 (pd-1) (pd-l1pd-1) immune checkpoint pathway. here, we demonstrate that pdt-mediated cancer immunotherapy can be augmented by pd-l1 knockdown (kd) in tumor cells. we rationally designed a versatile micelleplex by integrating an acid-activatable cationic micelle, photosensitizer (ps), and small interfering rna (sirna). the micelleplex was inert at physiological ph conditions and activated only upon internalization in the acidic endocytic vesicles of tumor cells for fluorescence imaging and pdt. compared to pdt alone, the combination of pdt and pd-l1 kd showed significantly enhanced efficacy for inhibiting tumor growth and distant metastasis in a b16-f10 melanoma xenograft tumor model. these results suggest that acid-activatable micelleplexes utilizing pdt-induced cancer immunotherapy are more effective when combined with sirna-mediated pd-l1 blockade. this study could provide a general strategy for enhancing the therapy efficacy of photodynamic cancer therapy. |
| WOS关键词 | HEAT-SHOCK PROTEINS ; FACTOR-KAPPA-B ; BREAST-CANCER ; ANTITUMOR IMMUNITY ; GENE DELIVERY ; THERAPY ; TUMORS ; CELLS ; COMBINATION ; NANOPARTICLES |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| WOS类目 | Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter |
| 语种 | 英语 |
| WOS记录号 | WOS:000383412100029 |
| 出版者 | AMER CHEMICAL SOC |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2376014 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Yu, Haijun; Li, Yaping |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Dangge,Wang, Tingting,Liu, Jianping,et al. Acid-activatable versatile micelleplexes for pd-l1 blockade enhanced cancer photodynamic immunotherapy[J]. Nano letters,2016,16(9):5503-5513. |
| APA | Wang, Dangge.,Wang, Tingting.,Liu, Jianping.,Yu, Haijun.,Jiao, Shi.,...&Li, Yaping.(2016).Acid-activatable versatile micelleplexes for pd-l1 blockade enhanced cancer photodynamic immunotherapy.Nano letters,16(9),5503-5513. |
| MLA | Wang, Dangge,et al."Acid-activatable versatile micelleplexes for pd-l1 blockade enhanced cancer photodynamic immunotherapy".Nano letters 16.9(2016):5503-5513. |
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来源：中国科学院大学
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