Inhibitory effects of ginkgolides on nitric oxide production in neonatal rat microglia in vitro
文献类型：期刊论文
| 作者 | Du, ZY; Li, XY |
| 刊名 | Acta pharmacologica sinica
 |
| 出版日期 | 1998-09-01 |
| 卷号 | 19期号:5页码:467-470 |
| 关键词 | Ginkgolides Platelet-activating factor Nitroarginine Nitric oxide Microglia Lipopolysaccharides Cultured cells Apafant |
| ISSN号 | 0253-9756 |
| 通讯作者 | Li, xy() |
| 英文摘要 | Aim: to study the effects of ginkgolide a (ga) and b (gb), apafant (apa), and n omega-nitro-l-arginine (l-na) on nitric oxide (no) production in cultured neonatal rat microglia. methods: no concentration was represented by nitrite which was determined by griess reaction. results: in resting microglia, no inhibitory effects of ga, gb, and apa were observed. l-na inhibited no production, its ic50 value (95 % confidence limits) being 3.4 (0.8-14.9) mu mol . l-1 ga, gb, and l-na inhibited no production in lss-stimulated microglia, and their ic50 values (95 % confidence limits) were 5.7 (1.8 - 18.1), 1.1 (0.3 - 4.4), and 0.5 (0.1 - 2.8) mu mol . l-1, respectively. apa did not inhibit no production. conclusion: ga and gb inhibited no production in lps-stimulated microglia. |
| WOS关键词 | ANTAGONISTS ; BRAIN ; INJURY ; CELLS |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| WOS类目 | Chemistry, Multidisciplinary ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000075784800018 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2376028 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Li, XY |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, Dept Pharmacol, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Du, ZY,Li, XY. Inhibitory effects of ginkgolides on nitric oxide production in neonatal rat microglia in vitro[J]. Acta pharmacologica sinica,1998,19(5):467-470. |
| APA | Du, ZY,&Li, XY.(1998).Inhibitory effects of ginkgolides on nitric oxide production in neonatal rat microglia in vitro.Acta pharmacologica sinica,19(5),467-470. |
| MLA | Du, ZY,et al."Inhibitory effects of ginkgolides on nitric oxide production in neonatal rat microglia in vitro".Acta pharmacologica sinica 19.5(1998):467-470. |
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来源：武汉病毒研究所
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