Pharmacokinetics of recombinant human granulocyte macrophage colony-stimulating factor in macaca mulatta
文献类型：期刊论文
| 作者 | Wang, RG; Zhu, XZ; Song, W |
| 刊名 | Acta pharmacologica sinica
 |
| 出版日期 | 1998 |
| 卷号 | 19期号:1页码:50-53 |
| 关键词 | Recombinant granulocyte macrophage colony-stimulating factor Enzyme-linked immunosorbent assay Pharmacokinetics Macaca mulatta |
| ISSN号 | 0253-9756 |
| 通讯作者 | Zhu, xz() |
| 英文摘要 | Aim: to examine the pharmacokinetics of iv and sc recombinant human granulocyte macrophage colony-stimulating factor (rhgm-csf) in macaca mulatta. methods: plasma levels of rhgm-csf were detected with sandwich enzyme-linked immunosorbent assay. results: plasma concentration-time curves after iv rhgm-csf in monkeys were best fitted with 3-compartment model. the 1st, 2nd, and 3rd phase t1/2 were 0.05-0.07, 0.14-0.58, and 1.4-4.1 h. cl and k-10 were similar between different doses, respectively. c-max was 0.93 +/- 0.16 mu g.l-1, t-max was 2.65 +/- 0.14 h, and elimination t1/2 was 2.5 +/- 0.3 h after: sc rhgm-csf. the bioavailability after sc rhgm-csf was 0.61. conclusion: pharmacokinetics of rhgm-csf in macaca mulatta provided a useful index for clinical trial. |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| WOS类目 | Chemistry, Multidisciplinary ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000071424500013 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2376035 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Zhu, XZ |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, Dept Pharmacol, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, RG,Zhu, XZ,Song, W. Pharmacokinetics of recombinant human granulocyte macrophage colony-stimulating factor in macaca mulatta[J]. Acta pharmacologica sinica,1998,19(1):50-53. |
| APA | Wang, RG,Zhu, XZ,&Song, W.(1998).Pharmacokinetics of recombinant human granulocyte macrophage colony-stimulating factor in macaca mulatta.Acta pharmacologica sinica,19(1),50-53. |
| MLA | Wang, RG,et al."Pharmacokinetics of recombinant human granulocyte macrophage colony-stimulating factor in macaca mulatta".Acta pharmacologica sinica 19.1(1998):50-53. |
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来源：武汉病毒研究所
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