D-1/d-2 dopamine receptor interaction in membrane abolished by 6-hydroxydopamine lesion
文献类型：期刊论文
| 作者 | Guo, X; Zou, LL; Jin, GZ |
| 刊名 | Life sciences
 |
| 出版日期 | 1998-05-29 |
| 卷号 | 63期号:1页码:Pl7-pl12 |
| 关键词 | Spiperone Sch23390 Radioligand assay D-1/d-2 interaction 6-hydroxydopamine |
| ISSN号 | 0024-3205 |
| 通讯作者 | Jin, gz() |
| 英文摘要 | D-1/d-2 interaction in rat striatum was investigated by examining the effect of the d-2 antagonist spiperone on the binding of [h-3]sch23390 to d-1 dopamine (da) receptors. in the presence of endogenous da, spiperone blocked d-2 receptors, then caused the increase of the binding of [h-3]sch23390 in rat striatal homogenate. after the 6-hydroxydopamine (6-ohda) lesion, the increase was not found even if in the addition of exogenous da. the results suggest that the d-2 antagonist can modify the interaction between endogenous da and d-1 receptors labeled with [h-3]sch23390, while 6-ohda lesion may change the state of d-1/d-2 interaction operating at the receptor level. (c) 1998 elsevier science inc. |
| WOS关键词 | D-2 RECEPTORS ; STIMULATION ; ANTAGONISTS ; AGONISTS ; BRAIN ; RATS ; LINK ; D1 |
| WOS研究方向 | Research & Experimental Medicine ; Pharmacology & Pharmacy |
| WOS类目 | Medicine, Research & Experimental ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000074036000010 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2376038 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Jin, GZ |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, Dept Pharmacol, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Guo, X,Zou, LL,Jin, GZ. D-1/d-2 dopamine receptor interaction in membrane abolished by 6-hydroxydopamine lesion[J]. Life sciences,1998,63(1):Pl7-pl12. |
| APA | Guo, X,Zou, LL,&Jin, GZ.(1998).D-1/d-2 dopamine receptor interaction in membrane abolished by 6-hydroxydopamine lesion.Life sciences,63(1),Pl7-pl12. |
| MLA | Guo, X,et al."D-1/d-2 dopamine receptor interaction in membrane abolished by 6-hydroxydopamine lesion".Life sciences 63.1(1998):Pl7-pl12. |
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来源：武汉病毒研究所
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