Basic fibroblast growth factor protected forebrain against ischemia-reperfusion damage in rats
文献类型：期刊论文
| 作者 | Liu, X; Zhu, XZ |
| 刊名 | Acta pharmacologica sinica
 |
| 出版日期 | 1998-11-01 |
| 卷号 | 19期号:6页码:527-530 |
| 关键词 | Basic fibroblast growth factor Reperfusion injury Visual cortex Dopamine Water Sodium Potassium High pressure liquid chromatography Corpus striatum |
| ISSN号 | 0253-9756 |
| 通讯作者 | Zhu, xz() |
| 英文摘要 | Aim: to study the effect of basic fibroblast growth factor (bfgf) on acute forebrain ischemia-reperfusion injury in rats. methods: both vertebral arteries were occluded by electrocautery and severe but transient bilateral cerebral ischemia was produced by clamping both common carotid arteries for 20 min in rats. the contents of dopamine (da) and 3,4-dihydroxyphenylacetic acid (dopac) in striatum were determined by hplc with electrochemic detector (hplc-ec) at 3, 6, 12, 24 h after the onset of reperfusion. the contents of sodium, potassium in forebrain were determined by atomic absorption spectro-photometric method at 6-h reperfusion. morphological changes of the striatum were also examined. results: at 6-h reperfusion, the da content in striatum decreased from (99 +/- 16) mu g . g(-1)(protein) in sham-operation group to (70 +/- 20) mu g . g(-1) (protein); the water and the sodium contents in forebrain increased from 77.34% +/- 0.19% to 79.6% +/- 0.6% and from (9.3 +/- 0.6) to (10.5 +/- 0.6) mg . g(-1) (dry weight), respectively, bfgf (iv 45 mu g . kg(-1) . h(-1) for 3 h) from the start of reperfusion prevented the decrease of da in striatum and the increases of water and sodium contents in forebrain. histological examination also indicated that bfgf ameliorated the injury of neurons. conclusion: bfgf prevented the brain from injury of ischemia and reperfusion. |
| WOS关键词 | FOCAL CEREBRAL-ISCHEMIA ; HIPPOCAMPAL-NEURONS ; NITRIC-OXIDE ; GLUTAMATE ; DOPAMINE |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| WOS类目 | Chemistry, Multidisciplinary ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000076914200007 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2376042 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Zhu, XZ |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, Dept Pharmacol, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, X,Zhu, XZ. Basic fibroblast growth factor protected forebrain against ischemia-reperfusion damage in rats[J]. Acta pharmacologica sinica,1998,19(6):527-530. |
| APA | Liu, X,&Zhu, XZ.(1998).Basic fibroblast growth factor protected forebrain against ischemia-reperfusion damage in rats.Acta pharmacologica sinica,19(6),527-530. |
| MLA | Liu, X,et al."Basic fibroblast growth factor protected forebrain against ischemia-reperfusion damage in rats".Acta pharmacologica sinica 19.6(1998):527-530. |
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来源：武汉病毒研究所
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