Neuroprotective rather than neurorescue or neurorestorative effect of selegiline against mptp-induced dopaminergic toxicity
文献类型：期刊论文
| 作者 | Wu, WR; Zhu, XZ; Guan, HJ; Wang, RG; Ji, XQ |
| 刊名 | Acta pharmacologica sinica
 |
| 出版日期 | 1999-02-01 |
| 卷号 | 20期号:2页码:146-150 |
| 关键词 | Selegiline Dopamine Corpus striatum High pressure liquid chromatography Kynuramine Quinolines Monoamine oxidase Fluorometry 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine Inbred c57bl mice |
| ISSN号 | 0253-9756 |
| 通讯作者 | Zhu, xz(xzzhu@server.shcnc.ac.cn) |
| 英文摘要 | Aim: to study the neuroprotective, neurorescue, neurorestorative effects of selegiline (sel) on nigrostriatal dopaminergic neuronal system and its inhibition of brain monoamine oxidase b (mao-b). methods: the striatal levels of dopamine and its metabolites were measure using hplc with electrochemical detection (hplc-ec). the inhibition of mao-b was tested by an improved fluorimetric assay. results: 1-methyl-4-phenyl-1,2,3,6-tetrahydro-pyridine (mptp) (30 mg . kg(-1) ip) reduced the striatal dopamine level by 73% in mice. selegiline (sel, 10 mg . kg(-1) ip) before, but not after, mptp treatment protected against mptp-induced nigrostriatal dopaminergic neurotoxicity. there were no differential effects between sel and saline treatments on the recovery of striatal dopamine levels, which were partially restored during 2 wk. 1-methyl-4-phenylpyridinium) (mpp+) (5 mg . kg(-1) ip) produced no dopaminergic neurotoxicity. furthermore, sel selectively and irreversibly inhibited mouse brain mao-b in vitro (ic50 = 17 nmol.l-1, 95% confidence limits = 14 - 20 nmol.l-1). conclusion: selegiline has neuroprotective rather than neurorescue or neurorestorative effects on mptp-induced nigrostriatal dopaminergic neuronal degeneration, which is directly pertinent to its selective and irreversible inhibition of brain mao-b activity. |
| WOS关键词 | L-DEPRENYL SELEGILINE ; PARKINSONS-DISEASE ; B INHIBITOR ; NEUROTOXICITY |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| WOS类目 | Chemistry, Multidisciplinary ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000078533100011 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2376044 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Zhu, XZ |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, Dept Pharmacol, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, WR,Zhu, XZ,Guan, HJ,et al. Neuroprotective rather than neurorescue or neurorestorative effect of selegiline against mptp-induced dopaminergic toxicity[J]. Acta pharmacologica sinica,1999,20(2):146-150. |
| APA | Wu, WR,Zhu, XZ,Guan, HJ,Wang, RG,&Ji, XQ.(1999).Neuroprotective rather than neurorescue or neurorestorative effect of selegiline against mptp-induced dopaminergic toxicity.Acta pharmacologica sinica,20(2),146-150. |
| MLA | Wu, WR,et al."Neuroprotective rather than neurorescue or neurorestorative effect of selegiline against mptp-induced dopaminergic toxicity".Acta pharmacologica sinica 20.2(1999):146-150. |
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来源：武汉病毒研究所
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