The amphetamine-like reinforcing effect and mechanism of l-deprenyl on conditioned place preference in mice
文献类型：期刊论文
| 作者 | Wu, WR; Zhu, XZ |
| 刊名 | European journal of pharmacology
 |
| 出版日期 | 1999 |
| 卷号 | 364期号:1页码:1-6 |
| 关键词 | L-deprenyl L-amphetamine Reinforcement Haloperidol Mptp (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) Dopamine |
| ISSN号 | 0014-2999 |
| 通讯作者 | Zhu, xz(xzzhu@server.shenc.ac.cn) |
| 英文摘要 | The present study investigated the reinforcing effect of l-deprenyl on conditioned place preference in mice and its mechanism. conditioned place preference was induced by 10 and 25 mg/kg l-deprenyl in a dose-dependent fashion during five consecutive conditioning days, and its reinforcing property was about five-fold less potent than that of l-amphetamine. pretreatment with the dopamine antagonist, haloperidol (1 mg/kg i.p.), effectively blocked the place preference produced by l-deprenyl (10 and 25 mg/kg i.p.) and l-amphetamine (2 and 5 mg/kg i.p.), but haloperidol itself produced no place aversion. the neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp), 30 mg/kg did not modify the place preference induced by both l-deprenyl and l-amphetamine, though the dopamine concentration in striata assayed by high performance liquid chromatography with electrochemical detection (hplc-ec) was significantly reduced. these results suggest that l-deprenyl has amphetamine-like reinforcing properties. the reinforcing effect of l-deprenyl may be mediated by central dopaminergic neuronal systems, while the nigrostriatal dopaminergic pathway is not involved. (c) 1999 elsevier science b.v. all rights reserved. |
| WOS关键词 | MONOAMINE-OXIDASE ; PARKINSONS-DISEASE ; DOPAMINE UPTAKE ; MAO-B ; SELEGILINE ; RATS ; INHIBITORS ; COCAINE ; DISCRIMINATION ; NEUROTOXICITY |
| WOS研究方向 | Pharmacology & Pharmacy |
| WOS类目 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000077909900001 |
| 出版者 | ELSEVIER SCIENCE BV |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2376047 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Zhu, XZ |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, Dept Pharmacol, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, WR,Zhu, XZ. The amphetamine-like reinforcing effect and mechanism of l-deprenyl on conditioned place preference in mice[J]. European journal of pharmacology,1999,364(1):1-6. |
| APA | Wu, WR,&Zhu, XZ.(1999).The amphetamine-like reinforcing effect and mechanism of l-deprenyl on conditioned place preference in mice.European journal of pharmacology,364(1),1-6. |
| MLA | Wu, WR,et al."The amphetamine-like reinforcing effect and mechanism of l-deprenyl on conditioned place preference in mice".European journal of pharmacology 364.1(1999):1-6. |
入库方式： iSwitch采集
来源：武汉病毒研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。