Supraspinal d-2 receptor involved in antinociception induced by l-tetrahydropalmatine
文献类型：期刊论文
| 作者 | Hu, JY; Jin, GZ |
| 刊名 | Acta pharmacologica sinica
 |
| 出版日期 | 1999-08-01 |
| 卷号 | 20期号:8页码:715-719 |
| 关键词 | Tetrahydropalmatine Dopamine receptors Quinpirole Spiperone Skf38393 Sch-23390 Naloxone Antinociception Non-narcotic analgesics |
| ISSN号 | 0253-9756 |
| 通讯作者 | Jin, gz() |
| 英文摘要 | Aim: to study the role of dopamine (da) receptors in ;-tetrahydropalmatine (l-thp)-induced antinociception. methods: the intraperitoneal tip) and intrathecal (ith) injections were used to give the drugs. the tail-flick test was used to assess the nociceptive threshold of rats. results: by ip injection, l-thp (10, 20, 40 mg . kg(-1)) as well as d-2 receptor antagonist spiperone (1, 2, 3 mg . kg(-1)) produced dose-dependent antinociceptive effects on the nociception of rats, while d-2 receptor agonist quinpirole, d-1 receptor agonist skf38393, and d-1 receptor antagonist sch-23390 showed no antinociception. moreover, l-thp- or spiperone-induced antinociception was markedly attenuated by quinpirole (2, 3 mg . kg(-1)) but not skf38393 or naloxone. on the other hand, ith quinpirole (20, 30, 40 mu g . kg(-1)) also induced a dose-dependent antinociception, while ith i-thp, spiperone, skf38393, and sch-23390 did not exhibit any antinociception. furthermore, ith spiperone (20, 30, 40 ccg.kg(-1)) but not sch-23390 dose-dependently antagonised the antinociception induced by quinpirole. l-thp (ith, 100, 200, 300 mu g.kg(-1)) also dramatically attenuated the quinpirole-induced antinociception with a dose-dependent relationship. conclusion: activating the spinal d-2 receptor or blocking the supraspinal d-2 receptor produces antinociception. d-1 receptor might be not directly involved in the antinociception. l-thp (as a d-2 antagonist) as well as spiperone produces antinociception via blocking the supraspinal d-2 receptor. |
| WOS关键词 | DOPAMINERGIC AGENTS ; RAT |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| WOS类目 | Chemistry, Multidisciplinary ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000081902700008 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2376049 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Jin, GZ |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, Dept Pharmacol, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hu, JY,Jin, GZ. Supraspinal d-2 receptor involved in antinociception induced by l-tetrahydropalmatine[J]. Acta pharmacologica sinica,1999,20(8):715-719. |
| APA | Hu, JY,&Jin, GZ.(1999).Supraspinal d-2 receptor involved in antinociception induced by l-tetrahydropalmatine.Acta pharmacologica sinica,20(8),715-719. |
| MLA | Hu, JY,et al."Supraspinal d-2 receptor involved in antinociception induced by l-tetrahydropalmatine".Acta pharmacologica sinica 20.8(1999):715-719. |
入库方式： iSwitch采集
来源：武汉病毒研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。