Comparison of some antineoplastic drugs on inhibiting thrombin catalizing fibrinogen clotting in vitro
文献类型：期刊论文
| 作者 | Lu, DY; Cao, JY; Huang, YP; Gong, L; Chen, XL; Chen, EH; Xu, B |
| 刊名 | Chinese medical journal
 |
| 出版日期 | 1999-11-01 |
| 卷号 | 112期号:11页码:1052-1053 |
| 关键词 | Fibrin Fibrinogen Antineoplastic drugs Neoplasm metastasis |
| ISSN号 | 0366-6999 |
| 通讯作者 | Lu, dy() |
| 英文摘要 | Objective to classify the effect of thrombin, the key enzyme which enables fibrinogen to form fibrin (fibrinogen clotting) on the formation of metastasis by comparing the inhibition of some antineoplastic drugs on fibrinogen clotting in vitro. methods time intervals of different drugs to reach a maximum od (340 nm) data in fibrinogen solution added with thrombin were used in this work. results it was found that l-4-oxalysine (8-40 mu g/ml) and arabinosyl cytosine (10-50 mu g/ml) could inhibit the effect of thrombin by extending the fibrinogen clotting time to 100% - 150% (p< 0.001) and 61% -100% (p < 0.001) while the other antimetastatic drugs razoxane, probimane, adriamycin, harringtonine homoharringtonine and alpha-anordrin at the treatment concentrations showed no such activity. the positive rate of drugs to thrombin activity was approximately 25%. conclusion it suggests that l-4-oxalysine and arabinosyl cytosine may even exhibit antimetastatic effect through thrombin-fibrinogen pathway, and thrombin might operate in tumor metastasis for only limited step but crutial to fibrin formation in tumor nodules. |
| WOS关键词 | TUMOR ; COAGULATION |
| WOS研究方向 | General & Internal Medicine |
| WOS类目 | Medicine, General & Internal |
| 语种 | 英语 |
| WOS记录号 | WOS:000083863800033 |
| 出版者 | CHINESE MEDICAL ASSOCIATION |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2376050 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Lu, DY |
| 作者单位 | 1.Shanghai Univ, Sch Life Sci, Shanghai 201800, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Dept Pharmacol, Shanghai 200031, Peoples R China 3.Cent Hosp Jing An Dist, Dept Oncol, Shanghai 200040, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lu, DY,Cao, JY,Huang, YP,et al. Comparison of some antineoplastic drugs on inhibiting thrombin catalizing fibrinogen clotting in vitro[J]. Chinese medical journal,1999,112(11):1052-1053. |
| APA | Lu, DY.,Cao, JY.,Huang, YP.,Gong, L.,Chen, XL.,...&Xu, B.(1999).Comparison of some antineoplastic drugs on inhibiting thrombin catalizing fibrinogen clotting in vitro.Chinese medical journal,112(11),1052-1053. |
| MLA | Lu, DY,et al."Comparison of some antineoplastic drugs on inhibiting thrombin catalizing fibrinogen clotting in vitro".Chinese medical journal 112.11(1999):1052-1053. |
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来源：武汉病毒研究所
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