Roles of p53, c-myc, bcl-2, bax and caspases in glutamate-induced neuronal apoptosis and the possible neuroprotective mechanism of basic fibroblast growth factor
文献类型：期刊论文
| 作者 | Liu, X; Zhu, XZ |
| 刊名 | Molecular brain research
 |
| 出版日期 | 1999-08-25 |
| 卷号 | 71期号:2页码:210-216 |
| 关键词 | Glutamate Neuron Apoptosis Bcl-2 Caspase Basic fibroblast growth factor |
| ISSN号 | 0169-328X |
| 通讯作者 | Zhu, xz() |
| 英文摘要 | By using flow-cytometric analysis, we examined the involvement of p53, c-myc, bcl-2 and bax in the glutamate-induced cell death in cultured cortical neurons. the activities of caspase-1-like and caspase-3-like proteases were also measured after the glutamate treatment. the apoptosis rate of the cells increased after 12 h and 24 h treatment with, glutamate. the temporal profile of p53, c-myc, bcl-2, bax expression and caspases activation after glutamate treatment suggest that bcl-2, c-myc and caspase-3 play important roles in the excitotoxic neuronal cell death. the down-regulation of bcl-2 may be an important early stage event, which may cause the activation of caspase-3, c-myc is also involved in the process of apoptosis though its precise role remains elusive. bfgf exhibited the capability to antagonize the neuronal apoptosis caused by glutamate. the antiapoptotic potential of bfgf may result from its attenuating effect on the down-regulation of bcl-2 induced by glutamate and, subsequently, blockade of apoptosis cascade. this may provide a possible explanation for its neuroprotective effect against ischemic cell death. (c) 1999 elsevier science b.v. all rights reserved. |
| WOS关键词 | CEREBELLAR GRANULE CELLS ; FLOW-CYTOMETRIC ANALYSIS ; CEREBRAL-ISCHEMIA ; DEATH ; EXPRESSION ; FAMILY ; GENE ; MITOCHONDRIA ; ACTIVATION ; DISORDERS |
| WOS研究方向 | Neurosciences & Neurology |
| WOS类目 | Neurosciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000082766700008 |
| 出版者 | ELSEVIER SCIENCE BV |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2376052 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Zhu, XZ |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, Dept Pharmacol, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, X,Zhu, XZ. Roles of p53, c-myc, bcl-2, bax and caspases in glutamate-induced neuronal apoptosis and the possible neuroprotective mechanism of basic fibroblast growth factor[J]. Molecular brain research,1999,71(2):210-216. |
| APA | Liu, X,&Zhu, XZ.(1999).Roles of p53, c-myc, bcl-2, bax and caspases in glutamate-induced neuronal apoptosis and the possible neuroprotective mechanism of basic fibroblast growth factor.Molecular brain research,71(2),210-216. |
| MLA | Liu, X,et al."Roles of p53, c-myc, bcl-2, bax and caspases in glutamate-induced neuronal apoptosis and the possible neuroprotective mechanism of basic fibroblast growth factor".Molecular brain research 71.2(1999):210-216. |
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来源：武汉病毒研究所
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