Involvement of monoamine oxidase inhibition in neuroprotective and neurorestorative effects of ginkgo biloba extract against mptp-induced nigrostriatal dopaminergic toxicity in c57 mice
文献类型：期刊论文
| 作者 | Wu, WR; Zhu, XZ |
| 刊名 | Life sciences
 |
| 出版日期 | 1999-06-04 |
| 卷号 | 65期号:2页码:157-164 |
| ISSN号 | 0024-3205 |
| 关键词 | Ginkgo biloba extract Ginkgolide a Ginkgolide b Mptp Dopamine Striatum Hplc Kynuramine 4-hydroxyquinoline Monoamine oxidase Fluorescence |
| 通讯作者 | Zhu, xz(xzzhu@server.shcnc.ac.cn) |
| 英文摘要 | The present study investigated the neuroprotective and neurorestorative effects of ginkgo biloba extract (egb 761) and its two components ginkgolides a (bn52020) and b (bn52021) in mice, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) (30 mg/kg/d ip for six days) significantly reduced striatal dopamine (da) levels in c57 mice measured by high performance liquid chromatography with electrochemical detection (hplc-ec). when c57 mice were pretreated with egb 761 (20, 50, 100 mg/kg/d ip) for 7 days and then treated with the same extract 30 min before mptp injection for 6 days, the neurotoxic effect of mptp was antagonized in a dose-dependent fashion. similar treatment with ginkgolides a and b (5, 10, 50 mg/kg/d ip) showed no protective effect. when c57 mice were treated with egb 761 (50 mg/kg/d ip) after mptp-lesion, the recovery of striatal dopamine (da) levels was accelerated. however, similar treatment with ginkgolides a or b (10 mg/kg/d ip) did not show any effect. egb 761, but not ginkgolides a and b, nonselectively inhibited mouse brain mao activity in vitro (ic(50) = 36.45 +/- 1.56 mu g/ml) tested by an improved fluorimetric assay. the results demonstrate that egb 761 administered before or after mptp treatment effectively protects against mptp-induced nigrostriatal dopaminergic neurotoxicity and that the inhibitory effect of egb 761 on brain mao may be involved in its neuroprotective effect. |
| WOS关键词 | PLATELET-ACTIVATING-FACTOR ; NEUROTOXICITY ; PARKINSONISM ; EFFICACY ; DISEASE |
| WOS研究方向 | Research & Experimental Medicine ; Pharmacology & Pharmacy |
| WOS类目 | Medicine, Research & Experimental ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| WOS记录号 | WOS:000080855800005 |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2376053 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Zhu, XZ |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, Dept Pharmacol, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, WR,Zhu, XZ. Involvement of monoamine oxidase inhibition in neuroprotective and neurorestorative effects of ginkgo biloba extract against mptp-induced nigrostriatal dopaminergic toxicity in c57 mice[J]. Life sciences,1999,65(2):157-164. |
| APA | Wu, WR,&Zhu, XZ.(1999).Involvement of monoamine oxidase inhibition in neuroprotective and neurorestorative effects of ginkgo biloba extract against mptp-induced nigrostriatal dopaminergic toxicity in c57 mice.Life sciences,65(2),157-164. |
| MLA | Wu, WR,et al."Involvement of monoamine oxidase inhibition in neuroprotective and neurorestorative effects of ginkgo biloba extract against mptp-induced nigrostriatal dopaminergic toxicity in c57 mice".Life sciences 65.2(1999):157-164. |
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来源：武汉病毒研究所
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