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Chinese Academy of Sciences Institutional Repositories Grid
Increased expression and nuclear accumulation of basic fibroblast growth factor in primary cultured astrocytes following ischemic-like insults

文献类型:期刊论文

作者Liu, X; Zhu, XZ
刊名Molecular brain research
出版日期1999-08-25
卷号71期号:2页码:171-177
关键词Basic fibroblast growth factor Fibroblast growth factor receptor Astrocyte Serum-free Glucose-free Glutamate
ISSN号0169-328X
通讯作者Zhu, xz()
英文摘要Basic fibroblast growth factor (bfgf) is a biological active polypeptide with potent trophic effects on neurons, glia and endothelial cells. in the present study, we examined the temporal expression profile of bfgf protein in cultured cortical astrocytes under ischemic-like conditions such as serum-free, glucose-free or glutamate application. a peak increase of bfgf level was observed at 24 h after the initiation of insults. a striking increase in the bfgf immunoreactivity and a moderate increase in the fibroblast growth factor receptor-1 (fgfr-1) immunoreactivity were also found in the astrocytes treated with serum- or glucose-deprivation or glutamate. the increased bfgf immunoreactivity and fgfr-1 immunoreactivity were mainly accumulated in the nuclei of astrocytes. the results suggest that the expression of bfgf and fgfr-1 in the astrocytes, especially in the nuclear interior, can be up-regulated under ischemic-like conditions and that the up-regulation of bfgf and fgfr-1 may play an important role in the maintenance and repair of the central nervous system (cns) after ischemia. (c) 1999 elsevier science b.v. all rights reserved.
WOS关键词FOCAL CEREBRAL-ISCHEMIA ; TRANSIENT FOREBRAIN ISCHEMIA ; REDUCES INFARCT SIZE ; RAT-BRAIN ; MESSENGER-RNA ; FACTOR IMMUNOREACTIVITY ; PROTEIN ; INDUCTION ; CELLS
WOS研究方向Neurosciences & Neurology
WOS类目Neurosciences
语种英语
WOS记录号WOS:000082766700004
出版者ELSEVIER SCIENCE BV
URI标识http://www.irgrid.ac.cn/handle/1471x/2376056
专题武汉病毒研究所
通讯作者Zhu, XZ
作者单位Chinese Acad Sci, Shanghai Inst Mat Med, Dept Pharmacol, Shanghai 200031, Peoples R China
推荐引用方式
GB/T 7714
Liu, X,Zhu, XZ. Increased expression and nuclear accumulation of basic fibroblast growth factor in primary cultured astrocytes following ischemic-like insults[J]. Molecular brain research,1999,71(2):171-177.
APA Liu, X,&Zhu, XZ.(1999).Increased expression and nuclear accumulation of basic fibroblast growth factor in primary cultured astrocytes following ischemic-like insults.Molecular brain research,71(2),171-177.
MLA Liu, X,et al."Increased expression and nuclear accumulation of basic fibroblast growth factor in primary cultured astrocytes following ischemic-like insults".Molecular brain research 71.2(1999):171-177.

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来源:武汉病毒研究所

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