L-stepholidine facilitates inhibition of mpfc da receptors on subcortical nac da release
文献类型：期刊论文
| 作者 | Zhu, ZT; Wu, WR; Fu, Y; Jin, GZ |
| 刊名 | Acta pharmacologica sinica
 |
| 出版日期 | 2000-07-01 |
| 卷号 | 21期号:7页码:663-667 |
| ISSN号 | 0253-9756 |
| 关键词 | Stepholidine Dopamine receptors Dopamine Microdialysis Amphetamine Prefrontal Cortex Nucleus accumbens 6-hydroxydopamine |
| 通讯作者 | Jin, gz() |
| 英文摘要 | Aim: to determine whether the d-1 agonistic action of (-)-stepholidine (spd) on the medial prefrontal cortex (mpfc) neuron is involved in the modulation of evoked subcortical dopamine (da) release from nucleus accumbens (nac) of rats. methods: with the microinjection of spd into the mpfc, the ventral tegmental area (vta)-stimulated or amphetamine (amp)-evoked da efflux in the nac was detected by microdialysis + hplc-ecd in the 6-hydroxydopamine (6-ohda)-lesioned and intact rats. results: the depletion of da in the mpfc did not modify both the basal level and the vta-stimulated da efflux in the nac, but significantly facilitated the amp (20 mu mol.l-1)-evoked da efflux within the nac. it indicates that the mpfc da system is involved in the regulation of evoked da release in the nac. besides, the amp-evoked increase of the extracellular da release in the nac was significantly attenuated by spd (10, 30 mmol . l-1) microinjection into the mpfc, though this injection of spd could not alter the response of da release by the stimulation of the vta. furthermore, the inhibitory effect of spd on the amp-evoked da efflux could be partially reversed by intravenous administration of d-1 antagonist sch-23390 (1 mg . kg(-1)), but not by d-2 antagonist spiperone. conclusion: spd is capable of enhancing the function of d1 receptors in the mpfc, by which it facilitates the inhibition of da release in the nac. |
| WOS关键词 | DOPAMINE DEPLETION ; PREFRONTAL CORTEX ; SCHIZOPHRENIA ; MODULATION ; STRESS ; RAT |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| WOS类目 | Chemistry, Multidisciplinary ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| WOS记录号 | WOS:000088146100019 |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2376058 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Jin, GZ |
| 作者单位 | Shanghai Inst Mat Med, Dept Pharmacol, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhu, ZT,Wu, WR,Fu, Y,et al. L-stepholidine facilitates inhibition of mpfc da receptors on subcortical nac da release[J]. Acta pharmacologica sinica,2000,21(7):663-667. |
| APA | Zhu, ZT,Wu, WR,Fu, Y,&Jin, GZ.(2000).L-stepholidine facilitates inhibition of mpfc da receptors on subcortical nac da release.Acta pharmacologica sinica,21(7),663-667. |
| MLA | Zhu, ZT,et al."L-stepholidine facilitates inhibition of mpfc da receptors on subcortical nac da release".Acta pharmacologica sinica 21.7(2000):663-667. |
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来源：武汉病毒研究所
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