Differential effects of l-deprenyl on mpp+- and mptp-induced dopamine overflow in microdialysates of striatum and nucleus accumbens
文献类型：期刊论文
| 作者 | Wu, WR; Zhu, ZT; Zhu, XZ |
| 刊名 | Life sciences
 |
| 出版日期 | 2000-06-08 |
| 卷号 | 67期号:3页码:241-250 |
| 关键词 | L-deprenyl Mpp+ (1-methyl-4-phenylpyridinium ion) Mptp (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) Striatum Nucleus accumbens Microdialysis |
| ISSN号 | 0024-3205 |
| 通讯作者 | Wu, wr() |
| 英文摘要 | The present studies investigated the effects of l-deprenyl, 1-methyl-4-phenylpyridinium ion (mpp+) and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) on the efflux of dopamine and its metabolites in microdialysates of striatum and nucleus accumbens in rats. l-deprenyl or l-amphetamine perfusion into striatum had no effects on basal dopamine efflux, though l-deprenyl reduced the basal efflux of dihydroxyphenylacetic acid and homovanillic acid. mpp+ or mptp perfusion into striatum significantly increased the dopamine efflux, and the action of mptp was more potent than that of mpp+. pretreatment with l-deprenyl antagonized the actions of mpp+ and mptp. the striatal dopamine efflux of rats was gradually restored by itself after the overflow caused by 2-h perfusion of the dopaminergic neurotoxins, while l-deprenyl could not accelerate the recovery. perfusion with l-deprenyl or l-amphetamine, but not pargyline, into nucleus accumbens increased the dopamine efflux in a dose-dependent fashion, which could be antagonized by haloperidol pretreatment, mpp+ or mptp perfusion into nucleus accumbens also increased the dopamine efflux, and the action of mptp was also more potent than that of mpp+. pretreatment with l-deprenyl could not antagonize the actions of mpp+ and mptp. these findings suggest that l-deprenyl, mpp+ and mptp induce differential effects on nigrostriatal and mesolimbic dopaminergic pathways in vivo. l-deprenyl has neuroprotective rather than neurorestorative action against mpp+- and mptp-induced dopamine overflow from striatum. further, l-deprenyl-induced dopamine overflow from nucleus accumbens may explain the amphetamine-like reinforcing property of l-deprenyl. (c) 2000 elsevier science inc. all rights reserved. |
| WOS关键词 | SELEGILINE ; NEUROTOXICITY ; NEUROTENSIN ; PATHWAYS ; TOXICITY ; SYSTEMS ; RAT |
| WOS研究方向 | Research & Experimental Medicine ; Pharmacology & Pharmacy |
| WOS类目 | Medicine, Research & Experimental ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000087709700004 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2376060 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Wu, WR |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, Dept Pharmacol, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, WR,Zhu, ZT,Zhu, XZ. Differential effects of l-deprenyl on mpp+- and mptp-induced dopamine overflow in microdialysates of striatum and nucleus accumbens[J]. Life sciences,2000,67(3):241-250. |
| APA | Wu, WR,Zhu, ZT,&Zhu, XZ.(2000).Differential effects of l-deprenyl on mpp+- and mptp-induced dopamine overflow in microdialysates of striatum and nucleus accumbens.Life sciences,67(3),241-250. |
| MLA | Wu, WR,et al."Differential effects of l-deprenyl on mpp+- and mptp-induced dopamine overflow in microdialysates of striatum and nucleus accumbens".Life sciences 67.3(2000):241-250. |
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来源：武汉病毒研究所
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