Mlkl and fadd are critical for suppressing progressive lymphoproliferative disease and activating the nlrp3 inflammasome
文献类型：期刊论文
| 作者 | Zhang, Xixi1; Fan, Cunxian1; Zhang, Haiwei1; Zhao, Qun1; Liu, Yongbo1; Xu, Chengxian1; Xie, Qun1,2; Wu, Xiaoxia1; Yu, Xianjun1,3; Zhang, Jianke4 |
| 刊名 | Cell reports
 |
| 出版日期 | 2016-09-20 |
| 卷号 | 16期号:12页码:3247-3259 |
| ISSN号 | 2211-1247 |
| DOI | 10.1016/j.celrep.2016.06.103 |
| 通讯作者 | Zhang, haibing(hbzhang@sibs.ac.cn) |
| 英文摘要 | Mlkl, a key component downstream of ripk3, is suggested to be a terminal executor of necroptosis. genetic studies have revealed that ripk3 ablation rescues embryonic lethality in fadd- or caspase-8-deficient mice. given that ripk3 has also been implicated in non-necroptotic pathways including apoptosis and inflammatory signaling, it remains unclear whether the lethality in fadd(-/-) mice is indeed caused by necropotosis. here, we show that genetic deletion of mlkl rescues the developmental defect in fadd-deficient mice and that fadd(-/-) mlkl(-/-) mice are viable and fertile. mlkl(-/-) fadd(-/-) mice display significantly accelerated lymphoproliferative disease characterized by lymphadenopathy and splenomegaly when compared to ripk3(-/-) fadd(-/-) mice. mlkl(-/-) fadd(-/-) bone-marrow-derived macrophages and dendritic cells have impaired nlrp3 inflammasome activation associated with defects in asc speck formation and nf-kappa b-dependent nlrp3 transcription. our findings reveal that mlkl and fadd play critical roles in preventing lymphoproliferative disease and activating the nlrp3 inflammasome. |
| WOS关键词 | MIXED LINEAGE KINASE ; DOMAIN-LIKE PROTEIN ; CELL-DEATH ; SIGNALING COMPLEX ; DEFICIENT MICE ; RIP3 KINASE ; CASPASE-8 ; APOPTOSIS ; NECROSIS ; NECROPTOSIS |
| WOS研究方向 | Cell Biology |
| WOS类目 | Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000383884200016 |
| 出版者 | CELL PRESS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2376063 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Zhang, Haibing |
| 作者单位 | 1.Chinese Acad Sci, Univ Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci,Key Lab Nutr & Metab, Shanghai 200031, Peoples R China 2.Second Mil Med Univ, Changhai Hosp, Dept Anesthesiol, Shanghai 200433, Peoples R China 3.Hubei Univ Med, Dept Biochem, Shiyan 442000, Peoples R China 4.Thomas Jefferson Univ, Sidney Kimmel Canc Ctr, Sidney Kimmel Med Coll, Dept Microbiol & Immunol, Philadelphia, PA 19107 USA |
| 推荐引用方式 GB/T 7714 | Zhang, Xixi,Fan, Cunxian,Zhang, Haiwei,et al. Mlkl and fadd are critical for suppressing progressive lymphoproliferative disease and activating the nlrp3 inflammasome[J]. Cell reports,2016,16(12):3247-3259. |
| APA | Zhang, Xixi.,Fan, Cunxian.,Zhang, Haiwei.,Zhao, Qun.,Liu, Yongbo.,...&Zhang, Haibing.(2016).Mlkl and fadd are critical for suppressing progressive lymphoproliferative disease and activating the nlrp3 inflammasome.Cell reports,16(12),3247-3259. |
| MLA | Zhang, Xixi,et al."Mlkl and fadd are critical for suppressing progressive lymphoproliferative disease and activating the nlrp3 inflammasome".Cell reports 16.12(2016):3247-3259. |
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来源：中国科学院大学
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