The rapid antidepressant and anxiolytic-like effects of yy-21 involve enhancement of excitatory synaptic transmission via activation of mtor signaling in the mpfc
文献类型：期刊论文
| 作者 | Guo, Fei1; Zhang, Bing1,2; Fu, Zhiwen1,2; Ma, Yuqin1,2; Gao, Yu1,2; Shen, Fuyi1,2; Huang, Chenggang1; Li, Yang1 |
| 刊名 | European neuropsychopharmacology
 |
| 出版日期 | 2016-07-01 |
| 卷号 | 26期号:7页码:1087-1098 |
| 关键词 | Yy-21 Mtor Synaptic transmission Synaptic proteins |
| ISSN号 | 0924-977X |
| DOI | 10.1016/j.euroneuro.2016.05.006 |
| 通讯作者 | Guo, fei(guofei@simm.ac.cn) ; Huang, chenggang(cghuang@simm.ac.cn) ; Li, yang(liyang@simm.ac.cn) |
| 英文摘要 | Although antidepressants have been widely prescribed to treat patients with major depressive disease (mdd), there is little disagreement over the need for improved antidepressant therapeutics as the typical treatments have a slow therapeutic onset and moderate efficacy. in the present study, we assessed a novel compound, yy-21, from timosaponin b-iii derived from sarsasapogenin of anemarrhenae rhizoma. from the initial results, we found that yy-21 obviously increased presynaptic glutamate release and enhanced long-term synaptic activity within 10 min as determined by excitatory postsynaptic current (epsc) and field excitatory postsynaptic potential (fepsp) in medial prefrontal cortex (mpfc) slices, respectively. yy-21 demonstrated anxiolytic-like effects following acute administration in naive animals and reversed the depressive-like and anxiety phenotypes induced by chronic unpredictable mild stress (cms) with a relatively fast therapeutic onset. furthermore, analysis of intracellular signaling pathways showed that yy-21 normalized the cms-induced low protein levels of glun2b, p-mtor, synaptic-related proteins, such as bdnf, psd-95 and glua1. pre-application of the mtor-selective inhibitor rapamycin blocked yy-21-induced long-term synaptic enhancement. these findings suggest that the activation of bdnf-dependent mtor signaling, which produces a rapid increase in the postsynaptic protein psd-95 and glua1 and further triggers the long-term enhancement of synaptic neurotransmission, may be the mechanism underlying the rapid antidepressant and anxiolytic effects induced by yy-21. (c) 2016 elsevier b.v. and ecnp. all rights reserved. |
| WOS关键词 | UNIPOLAR MOOD DISORDERS ; STAR-ASTERISK-D ; ANXIETY DISORDERS ; DEPRESSION ; STRESS ; BDNF ; CORTEX ; COMORBIDITY ; ANTAGONISTS ; MECHANISMS |
| WOS研究方向 | Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry |
| WOS类目 | Clinical Neurology ; Neurosciences ; Pharmacology & Pharmacy ; Psychiatry |
| 语种 | 英语 |
| WOS记录号 | WOS:000383340100001 |
| 出版者 | ELSEVIER SCIENCE BV |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2376079 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Guo, Fei; Huang, Chenggang; Li, Yang |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Key Lab Receptor Res, Shanghai 201203, Peoples R China 2.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Guo, Fei,Zhang, Bing,Fu, Zhiwen,et al. The rapid antidepressant and anxiolytic-like effects of yy-21 involve enhancement of excitatory synaptic transmission via activation of mtor signaling in the mpfc[J]. European neuropsychopharmacology,2016,26(7):1087-1098. |
| APA | Guo, Fei.,Zhang, Bing.,Fu, Zhiwen.,Ma, Yuqin.,Gao, Yu.,...&Li, Yang.(2016).The rapid antidepressant and anxiolytic-like effects of yy-21 involve enhancement of excitatory synaptic transmission via activation of mtor signaling in the mpfc.European neuropsychopharmacology,26(7),1087-1098. |
| MLA | Guo, Fei,et al."The rapid antidepressant and anxiolytic-like effects of yy-21 involve enhancement of excitatory synaptic transmission via activation of mtor signaling in the mpfc".European neuropsychopharmacology 26.7(2016):1087-1098. |
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来源：中国科学院大学
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