Neurotoxic effects of interleukin-6 and sodium nitroprusside on cultured rat hippocampal neurons
文献类型：期刊论文
| 作者 | Ma, TC; Zhu, XZ |
| 刊名 | Arzneimittel-forschung-drug research
 |
| 出版日期 | 2000-06-01 |
| 卷号 | 50期号:6页码:512-514 |
| 关键词 | Cas 2149-70-4 Cas 13755-38-9 Interleukin-6 Neurotoxicity, cell culture, hippocampal Nitric oxide |
| ISSN号 | 0004-4172 |
| 通讯作者 | Zhu, xz() |
| 英文摘要 | The neurotoxicity of interleukin-6 (il-6) and sodium nitroprusside (snp, cas 13755-38-9) was examined using primary cultures of rat hippocampal neurons. the cell viability was significantly reduced after the cultures were cn-incubated with il-6 4, 40, 400 ng/ml or snp 1, 10, 100 mu mol/l for 23 h. in addition, n omega-nitro-l-arginine (nna, cas 2149-70-4) at 0.1 mmol/l, when so-added with 1l-6 400 ng/ml in cultures, significantly increased il-6 reduced viability from 78.3 +/- 6.7 % to 113.3 +/- 10.0 %. these results indicate that il-6 exerts neurotoxicity on cultured hippocampal neurons probably via overformation of nitric oxide in cultures. |
| WOS关键词 | ALZHEIMERS-DISEASE ; NERVOUS-SYSTEM ; EXPRESSION ; CORTEX |
| WOS研究方向 | Pharmacology & Pharmacy ; Chemistry |
| WOS类目 | Chemistry, Medicinal ; Chemistry, Multidisciplinary ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000087965100002 |
| 出版者 | ECV-EDITIO CANTOR VERLAG MEDIZIN NATURWISSENSCHAFTEN |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2376086 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Zhu, XZ |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Dept Pharmacol, Shanghai 200031, Peoples R China 2.Louisiana State Univ, Med Ctr, Dept Pharmacol & Therapeut, Shreveport, LA 71130 USA |
| 推荐引用方式 GB/T 7714 | Ma, TC,Zhu, XZ. Neurotoxic effects of interleukin-6 and sodium nitroprusside on cultured rat hippocampal neurons[J]. Arzneimittel-forschung-drug research,2000,50(6):512-514. |
| APA | Ma, TC,&Zhu, XZ.(2000).Neurotoxic effects of interleukin-6 and sodium nitroprusside on cultured rat hippocampal neurons.Arzneimittel-forschung-drug research,50(6),512-514. |
| MLA | Ma, TC,et al."Neurotoxic effects of interleukin-6 and sodium nitroprusside on cultured rat hippocampal neurons".Arzneimittel-forschung-drug research 50.6(2000):512-514. |
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来源：武汉病毒研究所
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