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Chinese Academy of Sciences Institutional Repositories Grid
Neurotoxic effects of interleukin-6 and sodium nitroprusside on cultured rat hippocampal neurons

文献类型:期刊论文

作者Ma, TC; Zhu, XZ
刊名Arzneimittel-forschung-drug research
出版日期2000-06-01
卷号50期号:6页码:512-514
关键词Cas 2149-70-4 Cas 13755-38-9 Interleukin-6 Neurotoxicity, cell culture, hippocampal Nitric oxide
ISSN号0004-4172
通讯作者Zhu, xz()
英文摘要The neurotoxicity of interleukin-6 (il-6) and sodium nitroprusside (snp, cas 13755-38-9) was examined using primary cultures of rat hippocampal neurons. the cell viability was significantly reduced after the cultures were cn-incubated with il-6 4, 40, 400 ng/ml or snp 1, 10, 100 mu mol/l for 23 h. in addition, n omega-nitro-l-arginine (nna, cas 2149-70-4) at 0.1 mmol/l, when so-added with 1l-6 400 ng/ml in cultures, significantly increased il-6 reduced viability from 78.3 +/- 6.7 % to 113.3 +/- 10.0 %. these results indicate that il-6 exerts neurotoxicity on cultured hippocampal neurons probably via overformation of nitric oxide in cultures.
WOS关键词ALZHEIMERS-DISEASE ; NERVOUS-SYSTEM ; EXPRESSION ; CORTEX
WOS研究方向Pharmacology & Pharmacy ; Chemistry
WOS类目Chemistry, Medicinal ; Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000087965100002
出版者ECV-EDITIO CANTOR VERLAG MEDIZIN NATURWISSENSCHAFTEN
URI标识http://www.irgrid.ac.cn/handle/1471x/2376086
专题武汉病毒研究所
通讯作者Zhu, XZ
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, Dept Pharmacol, Shanghai 200031, Peoples R China
2.Louisiana State Univ, Med Ctr, Dept Pharmacol & Therapeut, Shreveport, LA 71130 USA
推荐引用方式
GB/T 7714
Ma, TC,Zhu, XZ. Neurotoxic effects of interleukin-6 and sodium nitroprusside on cultured rat hippocampal neurons[J]. Arzneimittel-forschung-drug research,2000,50(6):512-514.
APA Ma, TC,&Zhu, XZ.(2000).Neurotoxic effects of interleukin-6 and sodium nitroprusside on cultured rat hippocampal neurons.Arzneimittel-forschung-drug research,50(6),512-514.
MLA Ma, TC,et al."Neurotoxic effects of interleukin-6 and sodium nitroprusside on cultured rat hippocampal neurons".Arzneimittel-forschung-drug research 50.6(2000):512-514.

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来源:武汉病毒研究所

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