Effects of intrahippocampal infusion of interleukin-6 on passive avoidance and nitrite and prostaglandin levels in the hippocampus in rats
文献类型：期刊论文
| 作者 | Ma, TC; Zhu, XZ |
| 刊名 | Arzneimittel-forschung-drug research
 |
| 出版日期 | 2000-03-01 |
| 卷号 | 50期号:3页码:E227-e231 |
| 关键词 | Cas 53-86-1 Cas 2149-70-4 Indometacin Inlerleukin-6, in vivo studies, passive avoidance Pharmacology 6-keto-prostaglandin f-1 alpha Nitric oxide, hippocampal N-g-nitro-l-arginine |
| ISSN号 | 0004-4172 |
| 通讯作者 | Ma, tc() |
| 英文摘要 | Bilateral infusion of interleukin-6 (il-6) 80 ng into the hippocampus has been shown to impair retention of a step-through passive avoidance task via shortening the step-through latency in testing. this infusion with il-6 also increased the levels of nitrite and 6-ketoprostaglandin f-1 alpha (6-keto-pgf(1 alpha)) in rat hippocampus. in addition, intraperitoneal injection of n-g-nitro-l-arginine (cas 2149-70-4) 100 mg/kg for 5 days improved the retention impairment induced by il-6 and meanwhile antagonized the increase in nitrite levels. furthermore, intraperitoneal injection with indometacin (cas 53-86-1) 10 mg/kg daily for 5 days reduced the il-6-induced increase in 6-keto-pgf(1 alpha) levels. these results indicate that il-6 impairs retention of passive avoidance probably via the overproduction of nitric oxide (no) and suggest that il-6 may possess an inducible effect on no synthase and cyclo-oxygenase in the hippocampus. these findings support the hypothesis that central il-6 participates in the pathogenesis of alzheimer's disease, and the overproduction of nitric oxide in the brain may partially mediate the amnesic effect of il-6. |
| WOS关键词 | ALZHEIMERS-DISEASE ; OXIDE ; BRAIN |
| WOS研究方向 | Pharmacology & Pharmacy ; Chemistry |
| WOS类目 | Chemistry, Medicinal ; Chemistry, Multidisciplinary ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000086331200001 |
| 出版者 | ECV-EDITIO CANTOR VERLAG MEDIZIN NATURWISSENSCHAFTEN |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2376089 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Ma, TC |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Dept Pharmacol, Shanghai 200031, Peoples R China 2.Louisiana State Univ, Med Ctr, Dept Pharmacol & Therapeut, Shreveport, LA 71105 USA |
| 推荐引用方式 GB/T 7714 | Ma, TC,Zhu, XZ. Effects of intrahippocampal infusion of interleukin-6 on passive avoidance and nitrite and prostaglandin levels in the hippocampus in rats[J]. Arzneimittel-forschung-drug research,2000,50(3):E227-e231. |
| APA | Ma, TC,&Zhu, XZ.(2000).Effects of intrahippocampal infusion of interleukin-6 on passive avoidance and nitrite and prostaglandin levels in the hippocampus in rats.Arzneimittel-forschung-drug research,50(3),E227-e231. |
| MLA | Ma, TC,et al."Effects of intrahippocampal infusion of interleukin-6 on passive avoidance and nitrite and prostaglandin levels in the hippocampus in rats".Arzneimittel-forschung-drug research 50.3(2000):E227-e231. |
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来源：武汉病毒研究所
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