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Effects of intrahippocampal infusion of interleukin-6 on passive avoidance and nitrite and prostaglandin levels in the hippocampus in rats

文献类型:期刊论文

作者Ma, TC; Zhu, XZ
刊名Arzneimittel-forschung-drug research
出版日期2000-03-01
卷号50期号:3页码:E227-e231
关键词Cas 53-86-1 Cas 2149-70-4 Indometacin Inlerleukin-6, in vivo studies, passive avoidance Pharmacology 6-keto-prostaglandin f-1 alpha Nitric oxide, hippocampal N-g-nitro-l-arginine
ISSN号0004-4172
通讯作者Ma, tc()
英文摘要Bilateral infusion of interleukin-6 (il-6) 80 ng into the hippocampus has been shown to impair retention of a step-through passive avoidance task via shortening the step-through latency in testing. this infusion with il-6 also increased the levels of nitrite and 6-ketoprostaglandin f-1 alpha (6-keto-pgf(1 alpha)) in rat hippocampus. in addition, intraperitoneal injection of n-g-nitro-l-arginine (cas 2149-70-4) 100 mg/kg for 5 days improved the retention impairment induced by il-6 and meanwhile antagonized the increase in nitrite levels. furthermore, intraperitoneal injection with indometacin (cas 53-86-1) 10 mg/kg daily for 5 days reduced the il-6-induced increase in 6-keto-pgf(1 alpha) levels. these results indicate that il-6 impairs retention of passive avoidance probably via the overproduction of nitric oxide (no) and suggest that il-6 may possess an inducible effect on no synthase and cyclo-oxygenase in the hippocampus. these findings support the hypothesis that central il-6 participates in the pathogenesis of alzheimer's disease, and the overproduction of nitric oxide in the brain may partially mediate the amnesic effect of il-6.
WOS关键词ALZHEIMERS-DISEASE ; OXIDE ; BRAIN
WOS研究方向Pharmacology & Pharmacy ; Chemistry
WOS类目Chemistry, Medicinal ; Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000086331200001
出版者ECV-EDITIO CANTOR VERLAG MEDIZIN NATURWISSENSCHAFTEN
URI标识http://www.irgrid.ac.cn/handle/1471x/2376089
专题武汉病毒研究所
通讯作者Ma, TC
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, Dept Pharmacol, Shanghai 200031, Peoples R China
2.Louisiana State Univ, Med Ctr, Dept Pharmacol & Therapeut, Shreveport, LA 71105 USA
推荐引用方式
GB/T 7714
Ma, TC,Zhu, XZ. Effects of intrahippocampal infusion of interleukin-6 on passive avoidance and nitrite and prostaglandin levels in the hippocampus in rats[J]. Arzneimittel-forschung-drug research,2000,50(3):E227-e231.
APA Ma, TC,&Zhu, XZ.(2000).Effects of intrahippocampal infusion of interleukin-6 on passive avoidance and nitrite and prostaglandin levels in the hippocampus in rats.Arzneimittel-forschung-drug research,50(3),E227-e231.
MLA Ma, TC,et al."Effects of intrahippocampal infusion of interleukin-6 on passive avoidance and nitrite and prostaglandin levels in the hippocampus in rats".Arzneimittel-forschung-drug research 50.3(2000):E227-e231.

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来源:武汉病毒研究所

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