Endothelin mediates the altered renal hemodynamics associated with experimental congestive heart failure
文献类型：期刊论文
| 作者 | Qiu, CB; Ding, SS; Hess, P; Clozel, JP; Clozel, M |
| 刊名 | Journal of cardiovascular pharmacology
 |
| 出版日期 | 2001-08-01 |
| 卷号 | 38期号:2页码:317-324 |
| 关键词 | Tezosentan Endothelin Endothelin receptors Heart failure Myocardia infarction Renal hemodynamics |
| ISSN号 | 0160-2446 |
| 通讯作者 | Clozel, m() |
| 英文摘要 | Congestive heart failure (chf) is commonly associated with renal dysfunction. the goal of the current study was to evaluate the role of endothelin in the renal dysfunction of experimental chf by using tezosentan, a potent dual endothelin receptor antagonist. rats were subjected to coronary artery ligation. cardiac and renal hemodynamics were assessed after 3-5 weeks, when chf had developed. compared with control rats, chf rats had significantly higher left ventricular end-diastolic pressure (lvedp), lower mean arterial pressure, and reduced dp/dt(max). chf rats had severe renal vasoconstriction, as assessed by increased renal vascular resistance (rvr, p < 0.001), decreased renal plasma flow (rpf, p < 0.001), and glomerular filtration rate (gfr, p < 0.001). filtration fraction rose (p < 0.001). urine flow rate and sodium excretion were markedly lower. acute administration of tezosentan induced a marked decrease in lvedp without change of dp/dt(max) and heart rate. tezosentan decreased rvr (-43%, p < 0.001) and increased rpf and gfr. filtration fraction decreased slightly, tezosentan also increased urine flow rate and sodium excretion. these findings demonstrate that endothelin at least partly mediates the altered renal hemodynamics associated with experimental chf. dual endothelin receptor blockade could be useful for the improvement of both cardiac and renal function in chf. |
| WOS关键词 | NITRIC-OXIDE BLOCKADE ; MYOCARDIAL-INFARCTION ; ANGIOTENSIN-II ; INTRARENAL HEMODYNAMICS ; SIGNAL-TRANSDUCTION ; RAT-KIDNEY ; ANTAGONIST ; HYPERTENSION ; INHIBITION ; RESPONSES |
| WOS研究方向 | Cardiovascular System & Cardiology ; Pharmacology & Pharmacy |
| WOS类目 | Cardiac & Cardiovascular Systems ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000170020200017 |
| 出版者 | LIPPINCOTT WILLIAMS & WILKINS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2376095 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Clozel, M |
| 作者单位 | 1.Actel Pharmaceut Ltd, Innovat Ctr, CH-4123 Allschwil, Switzerland 2.Chinese Acad Sci, Shanghai Inst Mat Med, Dept Pharmacol, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Qiu, CB,Ding, SS,Hess, P,et al. Endothelin mediates the altered renal hemodynamics associated with experimental congestive heart failure[J]. Journal of cardiovascular pharmacology,2001,38(2):317-324. |
| APA | Qiu, CB,Ding, SS,Hess, P,Clozel, JP,&Clozel, M.(2001).Endothelin mediates the altered renal hemodynamics associated with experimental congestive heart failure.Journal of cardiovascular pharmacology,38(2),317-324. |
| MLA | Qiu, CB,et al."Endothelin mediates the altered renal hemodynamics associated with experimental congestive heart failure".Journal of cardiovascular pharmacology 38.2(2001):317-324. |
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来源：武汉病毒研究所
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