Synthesis and cytotoxicity of artemisinin derivatives containing cyanoarylmethyl group
文献类型：期刊论文
| 作者 | Wu, JM; Shan, F; Wu, GS; Li, Y; Ding, J; Xiao, D; Han, JX; Atassi, G; Leonce, S; Caignard, DH |
| 刊名 | European journal of medicinal chemistry
 |
| 出版日期 | 2001-05-01 |
| 卷号 | 36期号:5页码:469-479 |
| ISSN号 | 0223-5234 |
| 关键词 | Artemisinin derivatives Cyanoarylmethyl group Cytotoxicity |
| 通讯作者 | Li, y() |
| 英文摘要 | A series of 12 alpha -deoxoartemisinyl cyanoarylmethyl dicarboxylates (4a-4o), dicarboxylic acids 12 alpha -deoxoartemisinyl ester cyanoarylmethyl amide (5a-5k), and dicarboxylic acids 12 alpha -deoxoartemisinyl ester n-methylcyanoarylmethyl amide (6a-6l), showing moderate cytotoxicity against p388 and l1210 cells were prepared. they induced the significant accumulation of l1210 and p388 cells in the g1 phase of the cell cycle. this mechanism of action was quite different from that of the majority of cytotoxic compounds used in the chemotherapy of cancer. compound 4b possessed better cytotoxicity than the other compounds. (c) 2001 editions scientifiques et medicales elsevier sas. |
| WOS研究方向 | Pharmacology & Pharmacy |
| WOS类目 | Chemistry, Medicinal |
| 语种 | 英语 |
| 出版者 | EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER |
| WOS记录号 | WOS:000170409200007 |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2376096 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Li, Y |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Materia Med, Dept Synthet Chem, Shanghai 200031, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Materia Med, Dept Pharmacol, Shanghai 200031, Peoples R China 3.Inst Rech Servier, F-92150 Suresnes, France 4.ADIR & COMPAGNIE, Courbevoie, France |
| 推荐引用方式 GB/T 7714 | Wu, JM,Shan, F,Wu, GS,et al. Synthesis and cytotoxicity of artemisinin derivatives containing cyanoarylmethyl group[J]. European journal of medicinal chemistry,2001,36(5):469-479. |
| APA | Wu, JM.,Shan, F.,Wu, GS.,Li, Y.,Ding, J.,...&Renard, P.(2001).Synthesis and cytotoxicity of artemisinin derivatives containing cyanoarylmethyl group.European journal of medicinal chemistry,36(5),469-479. |
| MLA | Wu, JM,et al."Synthesis and cytotoxicity of artemisinin derivatives containing cyanoarylmethyl group".European journal of medicinal chemistry 36.5(2001):469-479. |
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来源：武汉病毒研究所
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