Additional effects of endothelin receptor blockade and angiotensin converting enzyme inhibition in rats with chronic heart failure
文献类型：期刊论文
| 作者 | Qiu, CB; Qiu, CS; Hess, P; Clozel, JP; Clozel, M |
| 刊名 | Acta pharmacologica sinica
 |
| 出版日期 | 2001-06-01 |
| 卷号 | 22期号:6页码:541-548 |
| 关键词 | Endothelins Endothelin receptors Tezosentan Angiotensin-converting enzyme inhibitors Myocardial infarction Congestive heart failure Hemo-dynamics Enalapril |
| ISSN号 | 0253-9756 |
| 通讯作者 | Qiu, cb() |
| 英文摘要 | Aim: to evaluate the acute effects of tezosentan, a new dual parenteral endothelin receptor antagonist, on hemodynamics in a rat model of chronic heart failure (chf), and further investigated if the combination of tezosentan with the angiotensin converting enzyme (ace) inhibitor, enalapril, had additive hemodynamic effect. methods: hemodynamics was measured in rats with chf, induced by ligation of the left coronary artery. results: at 3 to 5 weeks after myocardial infarction, rats developed chf. this was evidenced by a marked increase in left ventricular end-diastolic pressure (lvedp) with mean values of 23 to 26 mmhg, by a 30 % to 40 % reduction in left ventricular dp/dt(max) and by a more than 10 % decrease in mean arterial pressure (map) as compared to sham-operated rats. in chf rats, acute intravenous administration of either tezosentan (10 mg kg-l) or enalapril (1 mg . kg(-1)) markedly decreased map and lvedp, without affecting heart rate or dp/dt(max). tezosentan had additive effects on map and lvedp when given with enalapril compared with tezosentan (p < 0.05) or enalapril (p < 0.05) alone. there were no significant changes in heart rate and dp/dt(max) with the combination treatment compared with tezosentan- or enalapril-treated chf rats. conclusion: acute intravenous tezosentan improves cardiac hemodynamics and decreases lvedp and afterload (map) without changes in heart rate and cardiac contractility (dp/dt(max)) in chf mts. these favorable effects of tezosentan are similar to those of enalapril. furthermore, the benefits of tezosentan are apparent in addition to ace inhibition. thus, tezosentan could be a useful therapeutic agent in the acute treatment of heart failure. |
| WOS关键词 | VASOCONSTRICTION ; ANTAGONIST ; PROGRESSION ; ACTIVATION ; CAPTOPRIL ; SURVIVAL ; BOSENTAN ; THERAPY |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| WOS类目 | Chemistry, Multidisciplinary ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000169174700012 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2376098 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Qiu, CB |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Dept Pharmacol, Shanghai 200031, Peoples R China 2.Actel Ltd, CH-4123 Allschwil, Switzerland |
| 推荐引用方式 GB/T 7714 | Qiu, CB,Qiu, CS,Hess, P,et al. Additional effects of endothelin receptor blockade and angiotensin converting enzyme inhibition in rats with chronic heart failure[J]. Acta pharmacologica sinica,2001,22(6):541-548. |
| APA | Qiu, CB,Qiu, CS,Hess, P,Clozel, JP,&Clozel, M.(2001).Additional effects of endothelin receptor blockade and angiotensin converting enzyme inhibition in rats with chronic heart failure.Acta pharmacologica sinica,22(6),541-548. |
| MLA | Qiu, CB,et al."Additional effects of endothelin receptor blockade and angiotensin converting enzyme inhibition in rats with chronic heart failure".Acta pharmacologica sinica 22.6(2001):541-548. |
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来源：武汉病毒研究所
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