Short-term endothelin receptor blockade with tezosentan has both immediate and long-term beneficial effects in rats with myocardial infarction
文献类型：期刊论文
| 作者 | Clozel, M; Qiu, CB; Qiu, CS; Hess, P; Clozel, JP |
| 刊名 | Journal of the american college of cardiology
 |
| 出版日期 | 2002-01-02 |
| 卷号 | 39期号:1页码:142-147 |
| ISSN号 | 0735-1097 |
| 通讯作者 | Clozel, jp() |
| 英文摘要 | Objectives we investigated the effects of short-term tezosentan treatment on cardiac function, pulmonary edema and long-term evolution of heart failure (hf) in a rat model of myocardial infarction (mi). background endothelin (et) may play a major role in the progression from mi to hf. tezosentan is a new dual eta/etb receptor antagonist. methods rats were subjected to coronary artery ligation and were treated with either vehicle or tezosentan (10 mg/kg iv bolus) at 1 h and 24 h after mi. cardiac hemodynamics and lung weight were measured at 48 h after mi. survival was assessed over a five-month period. results at 48 h after ligation, vehicle-treated rats developed hf, as evidenced by a marked increase in left ventricular end-diastolic pressure (lvedp), reduction in dp/dt(max) and mean arterial pressure (map), and development of pulmonary edema. tezosentan treatment attenuated the increase in lvedp and in lung weight and slightly reduced map without affecting dp/dt(max). infarct size was not modified by tezosentan. despite the fact that treatment with tezosentan was stopped after 24 h, the initial tezosentan administration significantly reduced cardiac hypertrophy (22%) and decreased mortality by 51% at five months (50% survival vs. 19% survival in vehicle-treated rats, p < 0.001). conclusions tezosentan administered during the first day after mi in rats, in addition to improving acutely hemodynamic conditions, markedly increases long-term survival. this increase is associated with a decrease of pulmonary edema and prevention of cardiac hypertrophy. tezosentan could be a safe and useful therapeutic agent in the prevention and treatment of ischemic hf. (j am coll cardiol 2002;39:142-7) (c) 2002 by the american college of cardiology. |
| WOS关键词 | CHRONIC HEART-FAILURE ; ENDOGENOUS ENDOTHELIN ; ANTAGONIST BOSENTAN ; HYPERTENSIVE RATS ; BLOOD-PRESSURE ; CARDIAC-FUNCTION ; ALBUMIN ESCAPE ; CONSCIOUS RATS ; PLASMA-VOLUME ; LUNG INJURY |
| WOS研究方向 | Cardiovascular System & Cardiology |
| WOS类目 | Cardiac & Cardiovascular Systems |
| 语种 | 英语 |
| WOS记录号 | WOS:000173007500022 |
| 出版者 | ELSEVIER SCIENCE INC |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2376113 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Clozel, JP |
| 作者单位 | 1.Actelion Pharmaceut Ltd, Innovat Ctr, CH-4123 Allschwil, Switzerland 2.Shanghai Inst Mat Med, Dept Pharmacol, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Clozel, M,Qiu, CB,Qiu, CS,et al. Short-term endothelin receptor blockade with tezosentan has both immediate and long-term beneficial effects in rats with myocardial infarction[J]. Journal of the american college of cardiology,2002,39(1):142-147. |
| APA | Clozel, M,Qiu, CB,Qiu, CS,Hess, P,&Clozel, JP.(2002).Short-term endothelin receptor blockade with tezosentan has both immediate and long-term beneficial effects in rats with myocardial infarction.Journal of the american college of cardiology,39(1),142-147. |
| MLA | Clozel, M,et al."Short-term endothelin receptor blockade with tezosentan has both immediate and long-term beneficial effects in rats with myocardial infarction".Journal of the american college of cardiology 39.1(2002):142-147. |
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来源：武汉病毒研究所
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