Chronic endothelin receptor blockade prevents both early hyperfiltration and late overt diabetic nephropathy in the rat
文献类型：期刊论文
| 作者 | Ding, SS; Qiu, CB; Hess, P; Xi, JF; Zheng, N; Clozel, M |
| 刊名 | Journal of cardiovascular pharmacology
 |
| 出版日期 | 2003-07-01 |
| 卷号 | 42期号:1页码:48-54 |
| 关键词 | Bosentan Diabetic nephropathy Diabetes Endothelin Glomerulosclerosis |
| ISSN号 | 0160-2446 |
| 通讯作者 | Clozel, m() |
| 英文摘要 | Diabetic nephropathy is associated with enhanced renal synthesis of endothelin (et)-1. the goal of this study was to investigate the effects of dual et receptor antagonism in the early phase (2 months) and in the late phase (5 months) of diabetic nephropathy in rats, and to compare this approach to angiotensin-converting enzyme inhibition. four groups of uninephrectomized streptozotocin-induced diabetic rats were assigned to receive orally vehicle, bosentan, enalapril, or their combination. a fifth group consisted of nondiabetic, uninephrectomized rats. at 2 weeks, untreated diabetic rats exhibited increased glomerular filtration rate and renal plasma flow. bosentan, enalapril, and the combination all prevented hyperfiltration and hyperperfusion. by 5 months, diabetic rats developed marked increases in mean arterial pressure and renal vascular resistance, progressive proteinuria, and renal structural damage with glomerular sclerosis and hypertrophy. bosentan completely prevented the development of hypertension and renal vasoconstriction, and largely prevented the development of proteinuria and renal structural injury. the renal protective effect of bosentan was comparable to that of enalapril or the combination, although its anti-protein uric effect was less. clinical studies are warranted to assess whether et receptor antagonism can have additive effects on top of ace inhibition, the current treatment of choice in diabetic nephropathy. |
| WOS关键词 | CONVERTING ENZYME-INHIBITION ; NITRIC-OXIDE BLOCKADE ; ANGIOTENSIN-II ; SIGNAL-TRANSDUCTION ; GENE-EXPRESSION ; HEART-FAILURE ; ANTAGONIST ; GLOMERULOPATHY ; MELLITUS ; KIDNEY |
| WOS研究方向 | Cardiovascular System & Cardiology ; Pharmacology & Pharmacy |
| WOS类目 | Cardiac & Cardiovascular Systems ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000183897600008 |
| 出版者 | LIPPINCOTT WILLIAMS & WILKINS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2376124 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Clozel, M |
| 作者单位 | 1.Actelion Pharmaceut Ltd, CH-4123 Allschwil, Switzerland 2.Chinese Acad Sci, Shanghai Inst Mat Med, Dept Pharmacol, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ding, SS,Qiu, CB,Hess, P,et al. Chronic endothelin receptor blockade prevents both early hyperfiltration and late overt diabetic nephropathy in the rat[J]. Journal of cardiovascular pharmacology,2003,42(1):48-54. |
| APA | Ding, SS,Qiu, CB,Hess, P,Xi, JF,Zheng, N,&Clozel, M.(2003).Chronic endothelin receptor blockade prevents both early hyperfiltration and late overt diabetic nephropathy in the rat.Journal of cardiovascular pharmacology,42(1),48-54. |
| MLA | Ding, SS,et al."Chronic endothelin receptor blockade prevents both early hyperfiltration and late overt diabetic nephropathy in the rat".Journal of cardiovascular pharmacology 42.1(2003):48-54. |
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来源：武汉病毒研究所
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