Preparation, characterization and preliminary in vivo studies of inactivated sars-cov vaccine
文献类型：期刊论文
| 作者 | Tang, L; Wang, J; Qin, E; Zhu, QY; Yu, M; Ding, ZF; Shi, HY; Cheng, XJ; Wang, CP; Chang, GH |
| 刊名 | Chinese science bulletin
 |
| 出版日期 | 2003-12-01 |
| 卷号 | 48期号:23页码:2621-2625 |
| 关键词 | Sars Coronavirus Inactivated vaccine |
| ISSN号 | 1001-6538 |
| DOI | 10.1360/03wc464 |
| 通讯作者 | Wang, j() |
| 英文摘要 | A large quantity of sars-cov virus was proliferated in vero cells, inactivated with beta-propiolactone, then purified by sepharose 4ff column chromatography to prepare inactivated vaccine. the vaccine was identified by western blot, mass spectrographic analysis, elisa and electron microscopy. the vaccine with or without aluminum hydroxide adjuvant was inoculated into female balb/c mice at different dosages. the result showed that the antibodies to sars-cov were induced in the mice. the antibody levels induced by the vaccine with aluminum hydroxide were higher than those without aluminum hydroxide. |
| WOS关键词 | SELECTIVE INACTIVATION ; BETA-PROPIOLACTONE ; VIRAL GENOME ; B VIRUS ; INFLUENZA ; IMMUNIZATION ; PRINCIPLES ; ADJUVANTS |
| WOS研究方向 | Science & Technology - Other Topics |
| WOS类目 | Multidisciplinary Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000187511000018 |
| 出版者 | SCIENCE CHINA PRESS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2376127 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Wang, J |
| 作者单位 | 1.Chinese Acad Sci, Beijing Genom Inst, Beijing 101300, Peoples R China 2.Mil Med Acad, Inst Microbiol & Epidemiol, Beijing 100071, Peoples R China 3.Natl Vaccine & Serum Inst, Beijing 100024, Peoples R China 4.Chinese Acad Sci, Wuhan Inst Virol, Wuhan 430071, Peoples R China 5.Hunnan Normal Univ, Coll Life Sci, Changsha 410081, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tang, L,Wang, J,Qin, E,et al. Preparation, characterization and preliminary in vivo studies of inactivated sars-cov vaccine[J]. Chinese science bulletin,2003,48(23):2621-2625. |
| APA | Tang, L.,Wang, J.,Qin, E.,Zhu, QY.,Yu, M.,...&Chen, Z.(2003).Preparation, characterization and preliminary in vivo studies of inactivated sars-cov vaccine.Chinese science bulletin,48(23),2621-2625. |
| MLA | Tang, L,et al."Preparation, characterization and preliminary in vivo studies of inactivated sars-cov vaccine".Chinese science bulletin 48.23(2003):2621-2625. |
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来源：武汉病毒研究所
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