Serine racemase expression in mouse cerebral cortex after permanent focal cerebral ischemia
文献类型：期刊论文
| 作者 | Wang, LZ; Zhu, XZ |
| 刊名 | Acta pharmacologica sinica
 |
| 出版日期 | 2004-04-01 |
| 卷号 | 25期号:4页码:436-441 |
| 关键词 | D-serine L-serine Serine racemase Inbred c57bl mice Brain ischemia |
| ISSN号 | 1671-4083 |
| 通讯作者 | Zhu, xz(xzzhu@mail.shenc.ac.cn) |
| 英文摘要 | Aim: to study the alterations of the expressions of serine racemase in c57bl/6 mouse brain after permanent focal cerebral ischemia. methods: the mrna level and the protein level of serine racemase were assayed by semiquantitative reverse transcription polymerase chain reaction (rt-pcr) and western blot, respectively. the amount of d-serine and l-serine were measured by hplc. results: high levels of serine racemase were constitutively expressed in the normal cortex of mouse. at early stage after middle cerebral artery occlusion (mcao), no significant change in expression of serine racemase was observed in temporoparietal cortex in ipsilateral hemisphere. however, delayed transient decreases of serine racemase in both mrna and protein levels were detected from d 6 to d 10 after ischemia. correspondingly, d-serine concentration also declined in the ipsilateral cortex during, this period when compared with the d-serine level in the contralateral cortex. conclusion: delayed decreases in serine racemase expression and d-serine level occurred in the temporoparietal cortex at the late stage after focal cerebral ischemia. |
| WOS关键词 | GLYCINE SITE ; NMDA RECEPTOR ; RAT-BRAIN ; EXTRACELLULAR CONCENTRATION ; GLUTAMATE ; NEUROMODULATOR ; DAMAGE |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| WOS类目 | Chemistry, Multidisciplinary ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000220750000006 |
| 出版者 | SHANGHAI INST MATERIA MEDICA |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2376143 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Zhu, XZ |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Dept Pharmacol, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, LZ,Zhu, XZ. Serine racemase expression in mouse cerebral cortex after permanent focal cerebral ischemia[J]. Acta pharmacologica sinica,2004,25(4):436-441. |
| APA | Wang, LZ,&Zhu, XZ.(2004).Serine racemase expression in mouse cerebral cortex after permanent focal cerebral ischemia.Acta pharmacologica sinica,25(4),436-441. |
| MLA | Wang, LZ,et al."Serine racemase expression in mouse cerebral cortex after permanent focal cerebral ischemia".Acta pharmacologica sinica 25.4(2004):436-441. |
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来源：武汉病毒研究所
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