Heliocoverpa armigera single nucleocapsid nucleopolyhedrovirus induces hz-am1 cell cycle arrest at the g2 phase with accumulation of cyclin b-1
文献类型：期刊论文
| 作者 | Zhou, R; Yu, ZH; Li, XQ; Jia, F; Wu, JH; Chen, XW |
| 刊名 | Virus research
 |
| 出版日期 | 2004-10-01 |
| 卷号 | 105期号:2页码:113-120 |
| 关键词 | Cell cycle Hz-am1 cell Helicoverpa armigera single nucleocapsid nucleopolyhedrovirus Cyclin b-1 |
| ISSN号 | 0168-1702 |
| DOI | 10.1016/j.virusres.2004.05.001 |
| 通讯作者 | Yu, zh(chenxw@pentium.whiov.ac.cn) |
| 英文摘要 | The cell cycle phase distributions of hz-am1 cells grown in monolayer culture were g(1) = 49.7 +/- 3.3%, s = 22.7 +/- 3.8% and g(2)/m = 27.8 +/- 4.2% without >4n dna content. the culture doubling time was about 40 h and the duration of the g(1), s and g(2)/m phases was estimated to be 10, 14 and 16 h, respectively. hasnpv infection of hz-am1 cells resulted in both unsynchronized and synchronized g, phase arrest at g(2)/m phase. hasnpv infection also resulted in the appearance of more than 4n dna content, which accumulated to the highest levels 72 h post-infection. we also found that the expression level of cyclin b i increased significantly after 16 h post-infection, while cyclin a did not show any change. this observation supports the hz-am(1)-infected arrest at the g(2)/m phage. cytoplasm location of cyclin b-1 indicated that the hz-am1 cell cycle arrest was at the g(2) phase. (c) 2004 elsevier b.v. all rights reserved. |
| WOS关键词 | INFECTION ; VIRUS ; PHASE ; BACULOVIRUS ; LYMPHOCYTES ; EXPRESSION ; TRANSITION ; CULTURES |
| WOS研究方向 | Virology |
| WOS类目 | Virology |
| 语种 | 英语 |
| WOS记录号 | WOS:000224015200002 |
| 出版者 | ELSEVIER SCIENCE BV |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2376145 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Yu, ZH |
| 作者单位 | 1.Cent China Normal Univ, Inst Entomol, Wuhan 430070, Peoples R China 2.Huazhong Univ Sci & Technol, Tongji Hosp, Ctr Med, Dept Surg,Mol Med Ctr, Wuhan 430079, Peoples R China 3.Chinese Acad Sci, Wuhan Inst Virol, Key Lab Mol Virol, Wuhan 430071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhou, R,Yu, ZH,Li, XQ,et al. Heliocoverpa armigera single nucleocapsid nucleopolyhedrovirus induces hz-am1 cell cycle arrest at the g2 phase with accumulation of cyclin b-1[J]. Virus research,2004,105(2):113-120. |
| APA | Zhou, R,Yu, ZH,Li, XQ,Jia, F,Wu, JH,&Chen, XW.(2004).Heliocoverpa armigera single nucleocapsid nucleopolyhedrovirus induces hz-am1 cell cycle arrest at the g2 phase with accumulation of cyclin b-1.Virus research,105(2),113-120. |
| MLA | Zhou, R,et al."Heliocoverpa armigera single nucleocapsid nucleopolyhedrovirus induces hz-am1 cell cycle arrest at the g2 phase with accumulation of cyclin b-1".Virus research 105.2(2004):113-120. |
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来源：武汉病毒研究所
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