Decrease of ventral tegmental area dopamine neuronal activity in nicotine withdrawal rats
文献类型：期刊论文
| 作者 | Liu, ZH; Jin, WQ |
| 刊名 | Neuroreport
 |
| 出版日期 | 2004-06-28 |
| 卷号 | 15期号:9页码:1479-1481 |
| 关键词 | Dopamine Electrophysiology Nicotine Ventral tegmental area Withdrawal |
| ISSN号 | 0959-4965 |
| DOI | 10.1097/01.wnr.0000126218.25235.b6 |
| 通讯作者 | Jin, wq() |
| 英文摘要 | The present study was designed to examine the ventral tegmental area (vta) dopamine neuronal activity in nicotine withdrawal rats by means of in vivo single-unit extracellular recordings. animals were treated with nicotine base (6 mg/kg/day, s.c) four times daily for 12 days. one day after the last nicotine administration, the firing rates of the vta dopamine neurons were found to be significantly decreased. following 2, 3, 5 and 10 days of nicotine withdrawal, however, the firing rates returned to the control levels. the number of spontaneously active dopamine cells was not altered at any time points. the results indicate that the vta dopamine neuronal activity is reduced during the first day of nicotine withdrawal. |
| WOS关键词 | NUCLEUS-ACCUMBENS ; EXTRACELLULAR DOPAMINE ; PREFRONTAL CORTEX |
| WOS研究方向 | Neurosciences & Neurology |
| WOS类目 | Neurosciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000225140600023 |
| 出版者 | LIPPINCOTT WILLIAMS & WILKINS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2376148 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Jin, WQ |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Mat Med, Dept Pharmacol, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, ZH,Jin, WQ. Decrease of ventral tegmental area dopamine neuronal activity in nicotine withdrawal rats[J]. Neuroreport,2004,15(9):1479-1481. |
| APA | Liu, ZH,&Jin, WQ.(2004).Decrease of ventral tegmental area dopamine neuronal activity in nicotine withdrawal rats.Neuroreport,15(9),1479-1481. |
| MLA | Liu, ZH,et al."Decrease of ventral tegmental area dopamine neuronal activity in nicotine withdrawal rats".Neuroreport 15.9(2004):1479-1481. |
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来源：武汉病毒研究所
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