Bioactive spirobisnaphthalenes and lactones from a cup fungus plectania sp collected in the tibet plateau region
文献类型：期刊论文
| 作者 | Wang, Kai1,2; Bao, Li1; Ma, Ke1; Qi, Wei3,4; Song, Fuhang3; Yao, Yijian1; Yin, Wenbing1; Zhang, Lixin3; Huang, Ying5; Han, Junjie1 |
| 刊名 | European journal of organic chemistry
 |
| 出版日期 | 2016-09-01 |
| 期号 | 25页码:4338-4346 |
| 关键词 | Natural products Biological acitvity Lactones Toxicity |
| ISSN号 | 1434-193X |
| DOI | 10.1002/ejoc.201600562 |
| 通讯作者 | Liu, hongwei(liuhw@im.ac.cn) |
| 英文摘要 | Five new spirobisnaphthalenes (1-5), one new tetralone derivative (6), and six new lactones (7-12) together with the known compound urnucratin c (13) have been isolated from the solid culture of the cup fungus plectania sp. the structures of the new compounds were unambiguously elucidated on the basis of one-and two-dimensional nmr spectroscopy, high-resolution mass spectrometry, and circular dichroism (cd) spectroscopy. compounds 1-6 were found to be active against staphylococcus aureus, methicillin-resistant s. aureus (mrsa), bacillus subtilis, and pseudomonas aeruginosa. in addition, the cytotoxicities of 1-13 were evaluated against the hepg2 and k562 cell lines by using the cck8 assay. compounds 1-3 and 13 showed moderate cytotoxicity against hepg2 and k562 with ic50 values in the range 10.7-38.5 mu m. this is the first report of secondary metabolites from this cup fungus. |
| WOS关键词 | MUSHROOM HERICIUM-ERINACEUS ; CLADOSPIRONE BISEPOXIDE ; ABSOLUTE-CONFIGURATION ; SECONDARY METABOLITES ; STRUCTURE ELUCIDATION ; GALIELLALACTONE |
| WOS研究方向 | Chemistry |
| WOS类目 | Chemistry, Organic |
| 语种 | 英语 |
| WOS记录号 | WOS:000383624700017 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2376168 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Liu, Hongwei |
| 作者单位 | 1.Chinese Acad Sci, Inst Microbiol, State Key Lab Mycol, 1 Beichenxi Rd, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Savaid Med Sch, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Inst Microbiol, Key Lab Pathogen Microbiol & Immunol, 1 Beichenxi Rd, Beijing 100101, Peoples R China 4.Hebei Univ, Coll Life Sci, Baoding 071002, Hebei, Peoples R China 5.Chinese Acad Sci, Inst Microbiol, State Key Lab Microbial Resources, 1 Beichen West Rd, Beijing 100101, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Kai,Bao, Li,Ma, Ke,et al. Bioactive spirobisnaphthalenes and lactones from a cup fungus plectania sp collected in the tibet plateau region[J]. European journal of organic chemistry,2016(25):4338-4346. |
| APA | Wang, Kai.,Bao, Li.,Ma, Ke.,Qi, Wei.,Song, Fuhang.,...&Liu, Hongwei.(2016).Bioactive spirobisnaphthalenes and lactones from a cup fungus plectania sp collected in the tibet plateau region.European journal of organic chemistry(25),4338-4346. |
| MLA | Wang, Kai,et al."Bioactive spirobisnaphthalenes and lactones from a cup fungus plectania sp collected in the tibet plateau region".European journal of organic chemistry .25(2016):4338-4346. |
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来源：中国科学院大学
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