Fungal biotransformation of tanshinone results in [4+2] cycloaddition with sorbicillinol: evidence for enzyme catalysis and increased antibacterial activity
文献类型：期刊论文
| 作者 | He, Wenni1; Liu, Miaomiao1; Li, Xiaolin2; Zhang, Xiaoping3; Abdel-Mageed, Wael M.4,5; Li, Li6,7; Wang, Wenzhao8; Zhang, Jingyu1; Han, Jianying1,12; Dai, Huanqin1 |
| 刊名 | Applied microbiology and biotechnology
 |
| 出版日期 | 2016-10-01 |
| 卷号 | 100期号:19页码:8349-8357 |
| ISSN号 | 0175-7598 |
| 关键词 | Biotransformation [4+2] cycloaddition reaction Tanshinone iia Hypocrea sp |
| DOI | 10.1007/s00253-016-7488-6 |
| 通讯作者 | Zhang, lixin(zhanglixin@im.ac.cn) ; Liu, xueting(liuxt2010@gmail.com) |
| 英文摘要 | The biotransformation of tanshinone iia to a new antibacterial agent tanshisorbicin (1) by the fungus hypocrea sp. (as 3.17108) is described. the structure of tanshisorbicin is a hybrid of tanshinone iia (2) and sorbicillinol (3). the latter is a metabolite produced by hypocrea sp. the structure of tanshisorbicin was determined using mass spectrometry, nmr spectroscopy, and ecd calculations. the anti-mrsa activity of 1 was found to be significantly higher than that of the parent substrate tan iia. preliminary experiments indicate that tanshisorbicin is formed via a [4+2] cycloaddition reaction that is likely catalyzed by microbial enzyme. |
| WOS关键词 | DIELS-ALDER REACTION ; NATURAL-PRODUCTS ; VERTICILLIUM-INTERTEXTUM ; BIOSYNTHESIS ; BISORBICILLINOLIDE ; BISORBIBUTENOLIDE ; BIOAVAILABILITY ; IDENTIFICATION ; TRANSFORMATION ; INTERMEDIATE |
| WOS研究方向 | Biotechnology & Applied Microbiology |
| WOS类目 | Biotechnology & Applied Microbiology |
| 语种 | 英语 |
| 出版者 | SPRINGER |
| WOS记录号 | WOS:000383242500008 |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2376177 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Zhang, Lixin; Liu, Xueting |
| 作者单位 | 1.Chinese Acad Sci, Inst Microbiol, Key Lab Pathogen Microbiol & Immunol, Beijing 100101, Peoples R China 2.Sichuan Acad Agr Sci, Soil & Fertilizer Res Inst, Chengdu 610066, Peoples R China 3.Sichuan Agr Univ, Dept Microbiol, Coll Resource & Environm, Chengdu 611130, Peoples R China 4.King Saud Univ, Dept Pharmacognosy, Coll Pharm, Riyadh 11451, Saudi Arabia 5.Assiut Univ, Dept Pharmacognosy, Fac Pharm, Assiut 71526, Egypt 6.Chinese Acad Med Sci, Inst Mat Med, Dept Med Chem, Beijing 100050, Peoples R China 7.Peking Union Med Coll, Beijing 100050, Peoples R China 8.Chinese Acad Sci, Inst Microbiol, State Key Lab Mycol, Beijing, Peoples R China 9.Univ Texas Austin, Coll Pharm, Div Med Chem, Austin, TX 78712 USA 10.Univ Texas Austin, Dept Chem, Austin, TX 78712 USA |
| 推荐引用方式 GB/T 7714 | He, Wenni,Liu, Miaomiao,Li, Xiaolin,et al. Fungal biotransformation of tanshinone results in [4+2] cycloaddition with sorbicillinol: evidence for enzyme catalysis and increased antibacterial activity[J]. Applied microbiology and biotechnology,2016,100(19):8349-8357. |
| APA | He, Wenni.,Liu, Miaomiao.,Li, Xiaolin.,Zhang, Xiaoping.,Abdel-Mageed, Wael M..,...&Liu, Xueting.(2016).Fungal biotransformation of tanshinone results in [4+2] cycloaddition with sorbicillinol: evidence for enzyme catalysis and increased antibacterial activity.Applied microbiology and biotechnology,100(19),8349-8357. |
| MLA | He, Wenni,et al."Fungal biotransformation of tanshinone results in [4+2] cycloaddition with sorbicillinol: evidence for enzyme catalysis and increased antibacterial activity".Applied microbiology and biotechnology 100.19(2016):8349-8357. |
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来源：中国科学院大学
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