Preferential protection of genetic fidelity within open chromatin by the mismatch repair machinery
文献类型：期刊论文
| 作者 | Sun, Lue1,2,3; Zhang, Yan2; Zhang, Zhuqiang2; Zheng, Yong2; Du, Lilin3; Zhu, Bing2,4 |
| 刊名 | Journal of biological chemistry
 |
| 出版日期 | 2016-08-19 |
| 卷号 | 291期号:34页码:17692-17705 |
| 关键词 | Chromatin Chromatin regulation Dna repair Heterochromatin Mutagenesis mechanism |
| ISSN号 | 0021-9258 |
| DOI | 10.1074/jbc.m116.719971 |
| 通讯作者 | Zhu, bing(zhubing@ibp.ac.cn) |
| 英文摘要 | Epigenetic systems are well known for the roles they play in regulating the differential expression of the same genome in different cell types. however, epigenetic systems can also directly impact genomic integrity by protecting genetic sequences. using an experimental evolutionary approach, we studied rates of mutation in the fission yeast schizosaccharomyces pombe strains that lacked genes encoding several epigenetic regulators or mismatch repair components. we report that loss of a functional mismatch repair pathway in s. pombe resulted in the preferential enrichment of mutations in euchromatin, indicating that the mismatch repair machinery preferentially protected genetic fidelity in euchromatin. this preference is probably determined by differences in the accessibility of chromatin at distinct chromatin regions, which is supported by our observations that chromatin accessibility positively correlated with mutation rates in s. pombe or human cancer samples with deficiencies in mismatch repair. importantly, such positive correlation was not observed in s. pombe strains or human cancer samples with functional mismatch repair machinery. |
| WOS关键词 | YEAST SCHIZOSACCHAROMYCES-POMBE ; MUTATION-RATE VARIATION ; FISSION YEAST ; HUMAN GENOME ; DNA-REPLICATION ; SEQUENCING DATA ; TUMOR-CELLS ; HETEROCHROMATIN ; CANCER ; RATES |
| WOS研究方向 | Biochemistry & Molecular Biology |
| WOS类目 | Biochemistry & Molecular Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000383241300019 |
| 出版者 | AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2376277 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Zhu, Bing |
| 作者单位 | 1.Tsinghua Univ, Tsinghua Univ Peking Univ Natl Inst Biol Sci Join, Sch Life Sci, Beijing 100084, Peoples R China 2.Chinese Acad Sci, Natl Lab Biomacromol, CAS Ctr Excellence Biomacromol, Inst Biophys, Beijing 100101, Peoples R China 3.Natl Inst Biol Sci, Beijing 102206, Peoples R China 4.Univ Chinese Acad Sci, Coll Life Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Sun, Lue,Zhang, Yan,Zhang, Zhuqiang,et al. Preferential protection of genetic fidelity within open chromatin by the mismatch repair machinery[J]. Journal of biological chemistry,2016,291(34):17692-17705. |
| APA | Sun, Lue,Zhang, Yan,Zhang, Zhuqiang,Zheng, Yong,Du, Lilin,&Zhu, Bing.(2016).Preferential protection of genetic fidelity within open chromatin by the mismatch repair machinery.Journal of biological chemistry,291(34),17692-17705. |
| MLA | Sun, Lue,et al."Preferential protection of genetic fidelity within open chromatin by the mismatch repair machinery".Journal of biological chemistry 291.34(2016):17692-17705. |
入库方式： iSwitch采集
来源：中国科学院大学
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。