A beta-lactamase-imprinted responsive hydrogel for the treatment of antibiotic-resistant bacteria
文献类型：期刊论文
| 作者 | Li, Wen1,2,3; Dong, Kai1,2,3; Ren, Jinsong1,2; Qu, Xiaogang1,2 |
| 刊名 | Angewandte chemie-international edition
 |
| 出版日期 | 2016-07-04 |
| 卷号 | 55期号:28页码:8049-8053 |
| 关键词 | Antibiotics Antibiotic resistance Enzymes Molecular imprinting Responsive hydrogels |
| ISSN号 | 1433-7851 |
| DOI | 10.1002/anie.201600205 |
| 通讯作者 | Qu, xiaogang(xqu@ciac.ac.cn) |
| 英文摘要 | Antibiotics play important roles in infection treatment and prevention. however, the effectiveness of antibiotics is now threatened by the prevalence of drug-resistant bacteria. furthermore, antibiotic abuse and residues in the environment cause serious health issues. in this study, a stimuli-responsive imprinted hydrogel was fabricated by using beta-lactamase produced by bacteria for deactivating antibiotics as the template molecule. the imprinted hydrogel could initially trap beta-lactamase excreted by drug-resistant bacteria, thus making bacteria sensitive to antibiotics. after the bactericidal treatment, the "imprinted sites" on the hydrogel could be reversibly abolished with a temperature stimulus, which resulted in the reactivation of beta-lactamase to degrade antibiotic residues. we also present an example of the use of this antibacterial design to treat wound infection. |
| WOS关键词 | POLYMER NANOPARTICLES ; BORONATE AFFINITY ; CANCER-CELLS ; INHIBITORS ; NANOSENSOR ; PARTICLES ; DESIGN ; MILK |
| WOS研究方向 | Chemistry |
| WOS类目 | Chemistry, Multidisciplinary |
| 语种 | 英语 |
| WOS记录号 | WOS:000383253100029 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2376279 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Qu, Xiaogang |
| 作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, Biol Chem Lab, Changchun 130022, Peoples R China 2.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Rare Earth Resource Utilizat, Changchun 130022, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Wen,Dong, Kai,Ren, Jinsong,et al. A beta-lactamase-imprinted responsive hydrogel for the treatment of antibiotic-resistant bacteria[J]. Angewandte chemie-international edition,2016,55(28):8049-8053. |
| APA | Li, Wen,Dong, Kai,Ren, Jinsong,&Qu, Xiaogang.(2016).A beta-lactamase-imprinted responsive hydrogel for the treatment of antibiotic-resistant bacteria.Angewandte chemie-international edition,55(28),8049-8053. |
| MLA | Li, Wen,et al."A beta-lactamase-imprinted responsive hydrogel for the treatment of antibiotic-resistant bacteria".Angewandte chemie-international edition 55.28(2016):8049-8053. |
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来源：中国科学院大学
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