Low molecular weight fucoidan modulates p-selectin and alleviates diabetic nephropathy
文献类型：期刊论文
| 作者 | Xu, Yingjie1,2,3; Zhang, Quanbin1,2,5; Luo, Dali4; Wang, Jing1,2; Duan, Delin1,2,5 |
| 刊名 | International journal of biological macromolecules
 |
| 出版日期 | 2016-10-01 |
| 卷号 | 91页码:233-240 |
| 关键词 | Fucoidan Diabetic nephropathy P-selectin |
| ISSN号 | 0141-8130 |
| DOI | 10.1016/j.ijbiomac.2016.05.081 |
| 通讯作者 | Zhang, quanbin(qbzhang@qdio.ac.cn) ; Duan, delin(dlduan@qdio.ac.cn) |
| 英文摘要 | Diabetic nephropathy (dn) is a serious microvascular complication that can lead to chronic and end stage renal failure. it is understood that inflammation is associated with the onset and process of dn. low molecular weight fucoidan (lmwf) isolated from saccharina japonica has anti-inflammatory properties. therefore, this study aimed to explore the mechanism of lmwf in dn model induced by streptozotocin. the biochemical indices levels showed lmwf reduced the dn diagnostic indices to protect renal function. the he stained sections exhibited lmwf protected normal morphological structures and reduced inflammatory cell infiltration in the kidneys of dn rats. furthermore, the levels of p-selectin and selectin-dependent inflammatory cytokines resulting from lmwf were obviously decreased at both the transcriptional and protein levels. thus, our results found that lmwf protected the renal function in dn rats and alleviated inflammation through the modulation of p-selectin and inflammatory cytokines. lmwf may have therapeutic potential against dn. (c) 2016 elsevier b.v. all rights reserved. |
| WOS关键词 | LAMINARIA-JAPONICA ; TGF-BETA ; PATHOGENETIC MECHANISMS ; SACCHARINA-JAPONICA ; GENE-EXPRESSION ; TNF-ALPHA ; CELLS ; ADHESION ; INJURY ; INFLAMMATION |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry ; Polymer Science |
| WOS类目 | Biochemistry & Molecular Biology ; Chemistry, Applied ; Polymer Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000382339200028 |
| 出版者 | ELSEVIER SCIENCE BV |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2376323 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Zhang, Quanbin; Duan, Delin |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Capital Med Univ, Sch Chem Biol & Pharmaceut Sci, Dept Pharmacol, Beijing 100069, Peoples R China 5.State Key Lab Seaweed Bioact Subst, Qingdao 266000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Yingjie,Zhang, Quanbin,Luo, Dali,et al. Low molecular weight fucoidan modulates p-selectin and alleviates diabetic nephropathy[J]. International journal of biological macromolecules,2016,91:233-240. |
| APA | Xu, Yingjie,Zhang, Quanbin,Luo, Dali,Wang, Jing,&Duan, Delin.(2016).Low molecular weight fucoidan modulates p-selectin and alleviates diabetic nephropathy.International journal of biological macromolecules,91,233-240. |
| MLA | Xu, Yingjie,et al."Low molecular weight fucoidan modulates p-selectin and alleviates diabetic nephropathy".International journal of biological macromolecules 91(2016):233-240. |
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来源：中国科学院大学
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