Noncoding rnas and their functional involvement in regulation of chronic myeloid leukemia
文献类型：期刊论文
| 作者 | Wang, Xuefei2; Chen, Ke2; Guo, Guijie1; Chen, Ji-Long3,4 |
| 刊名 | Briefings in functional genomics
 |
| 出版日期 | 2016-05-01 |
| 卷号 | 15期号:3页码:239-248 |
| 关键词 | Cml Cancer Micrornas Lncrnas Bcr-abl |
| ISSN号 | 2041-2649 |
| DOI | 10.1093/bfgp/elv059 |
| 通讯作者 | Chen, ji-long(chenjl@im.ac.cn) |
| 英文摘要 | Noncoding rnas (ncrnas) comprise multiple classes of transcripts that have no protein-coding ability but play critical roles as rna regulators in various cellular processes. to date, the well-studied ncrnas are micrornas (mirs) that generally act as regulators of gene expression through binding to target mrnas. recent advances in high-throughput sequencing technologies have led to the discovery of thousands of unannotated noncoding transcripts, especially long noncoding rnas (lncrnas). these lncrnas are being increasingly recognized as key regulators in diverse biological processes via a variety of mechanisms. aberrant expression of mirs and lncrnas has been shown to be associated with many human diseases and cancers. increasing ncrnas have been identified as biomarkers for patient prognosis and potential therapeutic agents for cancers. furthermore, it is worth noting that progresses have been made in understanding the functional involvement of ncrnas in bcr-abl-induced chronic myeloid leukemia (cml). here, we highlight the pathogenesis of cml, functional significance of mirs and lncrnas in regulation of cml development and involved mechanisms underlying their action. |
| WOS关键词 | CHRONIC MYELOGENOUS LEUKEMIA ; COMPETING ENDOGENOUS RNA ; B-CELL LYMPHOMA ; BCR-ABL ; GENE-EXPRESSION ; INITIATING CELLS ; GASTRIC-CANCER ; MESSENGER-RNA ; TUMOR-SUPPRESSOR ; DOWN-REGULATION |
| WOS研究方向 | Biotechnology & Applied Microbiology ; Genetics & Heredity |
| WOS类目 | Biotechnology & Applied Microbiology ; Genetics & Heredity |
| 语种 | 英语 |
| WOS记录号 | WOS:000383103200008 |
| 出版者 | OXFORD UNIV PRESS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2376324 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Chen, Ji-Long |
| 作者单位 | 1.Chinese Acad Sci, Inst Microbiol, CAS Key Lab Pathogen Microbiol & Immunol, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Chinese Acad Sci, Inst Microbiol, Beijing 100864, Peoples R China 4.Fujian Agr & Forestry Univ, Coll Anim Sci, Fuzhou, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Xuefei,Chen, Ke,Guo, Guijie,et al. Noncoding rnas and their functional involvement in regulation of chronic myeloid leukemia[J]. Briefings in functional genomics,2016,15(3):239-248. |
| APA | Wang, Xuefei,Chen, Ke,Guo, Guijie,&Chen, Ji-Long.(2016).Noncoding rnas and their functional involvement in regulation of chronic myeloid leukemia.Briefings in functional genomics,15(3),239-248. |
| MLA | Wang, Xuefei,et al."Noncoding rnas and their functional involvement in regulation of chronic myeloid leukemia".Briefings in functional genomics 15.3(2016):239-248. |
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来源：中国科学院大学
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