Thermosensitive polypeptide hydrogels as a platform for ros-triggered cargo release with innate cytoprotective ability under oxidative stress
文献类型：期刊论文
| 作者 | Xu, Qinghua1,2; He, Chaoliang1; Ren, Kaixuan1; Xiao, Chunsheng1; Chen, Xuesi1 |
| 刊名 | Advanced healthcare materials
 |
| 出版日期 | 2016-08-10 |
| 卷号 | 5期号:15页码:1979-1990 |
| 关键词 | Cell protection Oxidation-responsive hydrogel Poly(l-methionine) Thermosensitive hydrogel Triggered drug release |
| ISSN号 | 2192-2640 |
| DOI | 10.1002/adhm.201600292 |
| 通讯作者 | He, chaoliang(clhe@ciac.ac.cn) ; Chen, xuesi(xschen@ciac.ac.cn) |
| 英文摘要 | Reactive oxygen species (ros) play important roles in cell signaling pathways, while increased production of ros may disrupt cellular homeostasis, giving rise to a series of diseases. therefore, materials responding to ros at physiological levels are of great significance. in this work, a novel ros-responsive thermogelling hydrogel based on methoxy poly(ethylene glycol)-poly(l-methionine) diblock copolymers is designed and synthesized. the mechanism for solution-to-hydrogel (sol-gel) phase transitions of the copolymer aqueous solutions is studied. incubation of the hydrogels in the presence of peroxide hydrogen (h2o2 ) displays a h2o2-responsive degradation process. the hydrogels containing rhodamine 6g exhibit sustained release profiles that are accelerated in response to h2o2. an innate cytoprotective ability of the hydrogels is revealed by incubation of l929 cells with the hydrogels under oxidative stress, which reduces h2o2-mediated cell death. ros produced by activated macrophages can accelerate the erosion of the hydrogel, suggesting that the hydrogel is also responsive to pathological level of h2o2. meanwhile, the poly(l-methionine)-based hydrogels degrade within 6 weeks after subcutaneous injection into rats, with a good biocompatibility in vivo. overall, the injectable, ros-responsive hydrogels may serve as promising platforms for sustained drug delivery and cell-based therapies in treatment of diseases with local oxidative stress. |
| WOS关键词 | ACID-N-CARBOXYANHYDRIDES ; METHIONINE SULFOXIDE ; ANTIOXIDANT DEFENSE ; IN-VIVO ; BIOMEDICAL MATERIALS ; DRUG-DELIVERY ; PEROXIDE ; INFLAMMATION ; DEGRADATION ; APOPTOSIS |
| WOS研究方向 | Engineering ; Science & Technology - Other Topics ; Materials Science |
| WOS类目 | Engineering, Biomedical ; Nanoscience & Nanotechnology ; Materials Science, Biomaterials |
| 语种 | 英语 |
| WOS记录号 | WOS:000382772400020 |
| 出版者 | WILEY-BLACKWELL |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2376326 |
| 专题 | 中国科学院大学 |
| 通讯作者 | He, Chaoliang; Chen, Xuesi |
| 作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, Key Lab Polymer Ecomat, Changchun 130022, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Qinghua,He, Chaoliang,Ren, Kaixuan,et al. Thermosensitive polypeptide hydrogels as a platform for ros-triggered cargo release with innate cytoprotective ability under oxidative stress[J]. Advanced healthcare materials,2016,5(15):1979-1990. |
| APA | Xu, Qinghua,He, Chaoliang,Ren, Kaixuan,Xiao, Chunsheng,&Chen, Xuesi.(2016).Thermosensitive polypeptide hydrogels as a platform for ros-triggered cargo release with innate cytoprotective ability under oxidative stress.Advanced healthcare materials,5(15),1979-1990. |
| MLA | Xu, Qinghua,et al."Thermosensitive polypeptide hydrogels as a platform for ros-triggered cargo release with innate cytoprotective ability under oxidative stress".Advanced healthcare materials 5.15(2016):1979-1990. |
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来源：中国科学院大学
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