Tegument protein orf45 plays an essential role in virion morphogenesis of murine gammaherpesvirus 68
文献类型：期刊论文
| 作者 | Jia, Xing1,2; Shen, Sheng1; Lv, Ying1,2; Zhang, Ziwei1,2; Guo, Haitao1; Deng, Hongyu1,3 |
| 刊名 | Journal of virology
 |
| 出版日期 | 2016-08-01 |
| 卷号 | 90期号:16页码:7587-7592 |
| ISSN号 | 0022-538X |
| DOI | 10.1128/jvi.03231-15 |
| 通讯作者 | Deng, hongyu(hydeng@moon.ibp.ac.cn) |
| 英文摘要 | Tegument proteins play critical roles in herpesvirus morphogenesis. orf45 is a conserved tegument protein of gammaherpes-viruses; however, its role in virion morphogenesis is largely unknown. in this work, we determined the ultrastructural localization of murine gammaherpesvirus 68 (mhv-68) orf45 and found that this protein was incorporated into virions around the site of host-derived vesicles. notably, the absence of orf45 inhibited nucleocapsid egress and blocked cytoplasmic virion maturation, demonstrating that orf45 is essential for mhv-68 virion morphogenesis. |
| WOS关键词 | SARCOMA-ASSOCIATED HERPESVIRUS ; SECONDARY ENVELOPMENT ; EGRESS ; PHOSPHORYLATION ; IDENTIFICATION ; REPLICATION ; INTERFERON ; ORF33 ; ORF52 ; CELLS |
| WOS研究方向 | Virology |
| WOS类目 | Virology |
| 语种 | 英语 |
| WOS记录号 | WOS:000382306500045 |
| 出版者 | AMER SOC MICROBIOLOGY |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2376336 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Deng, Hongyu |
| 作者单位 | 1.Chinese Acad Sci, Key Lab Infect & Immun, Inst Biophys, Beijing, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Chinese Acad Sci, Inst Biophys, CAS Ctr Excellence Biomacromol, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jia, Xing,Shen, Sheng,Lv, Ying,et al. Tegument protein orf45 plays an essential role in virion morphogenesis of murine gammaherpesvirus 68[J]. Journal of virology,2016,90(16):7587-7592. |
| APA | Jia, Xing,Shen, Sheng,Lv, Ying,Zhang, Ziwei,Guo, Haitao,&Deng, Hongyu.(2016).Tegument protein orf45 plays an essential role in virion morphogenesis of murine gammaherpesvirus 68.Journal of virology,90(16),7587-7592. |
| MLA | Jia, Xing,et al."Tegument protein orf45 plays an essential role in virion morphogenesis of murine gammaherpesvirus 68".Journal of virology 90.16(2016):7587-7592. |
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来源：中国科学院大学
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