Nicotine-induced acute hyperactivity is mediated by dopaminergic system in a sexually dimorphic manner
文献类型：期刊论文
| 作者 | Zhang, Yunpeng1,2; Guo, Jing1; Guo, Aike1,3; Li, Yan1 |
| 刊名 | Neuroscience
 |
| 出版日期 | 2016-09-22 |
| 卷号 | 332页码:149-159 |
| 关键词 | Nicotine Locomotor hyperactivity Drosophila Dopaminergic neurons Sexual dimorphism Beta 1 nachr |
| ISSN号 | 0306-4522 |
| DOI | 10.1016/j.neuroscience.2016.06.043 |
| 通讯作者 | Li, yan(liyan@ibp.ac.cn) |
| 英文摘要 | Short-term exposure to nicotine induces positive effects in mice, monkeys and humans, including mild euphoria, hyperactivity, and enhanced cognition. however, the underlying neural basis and molecular mechanisms for these effects remain poorly understood. here, using a video recording system, we find that acute nicotine administration induces locomotor hyperactivity in drosophila, similar to observations made in higher model organisms. suppressing dopaminergic neurons or down-regulating dopamine 1-like receptor (dopr) abolishes this acute nicotine response, but surprisingly, does so only in male flies. using a gfp reconstitution across synaptic partners (grasp) approach, we show that dopaminergic neurons possess potential synaptic connections with acetylcholinergic neurons in wide regions of the brain. furthermore, dopaminergic neurons are widely activated upon nicotine perfusion in both sexes, while the response curve differs significantly between the sexes. moreover, knockdown of the 131 nicotine acetylcholine receptor (nachr) in dopaminergic neurons abolishes the acute nicotine response only in male flies, while panneural knock-down occurs in both sexes. taken together, our results reveal that in fruit flies, dopaminergic neurons mediate nicotine-induced acute locomotor hyperactivity in a sexually dimorphic manner, and drosophila pi nachr subunit plays a crucial role in this nicotine response. these findings provide important insights into the molecular and neural basis of acute nicotine effects, and the underlying mechanisms may play conserved roles across species. (c) 2016 ibro. published by elsevier ltd. all rights reserved. |
| WOS关键词 | CENTRAL-NERVOUS-SYSTEM ; ACETYLCHOLINE-RECEPTORS ; DROSOPHILA-MELANOGASTER ; LOCOMOTOR-ACTIVITY ; SUBUNIT ; BEHAVIOR ; ADDICTION ; RESPONSES ; NEURONS ; SLEEP |
| WOS研究方向 | Neurosciences & Neurology |
| WOS类目 | Neurosciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000381329800013 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2376338 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Li, Yan |
| 作者单位 | 1.Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Shanghai Inst Biol Sci, State Key Lab Neurosci, Inst Neurosci, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Yunpeng,Guo, Jing,Guo, Aike,et al. Nicotine-induced acute hyperactivity is mediated by dopaminergic system in a sexually dimorphic manner[J]. Neuroscience,2016,332:149-159. |
| APA | Zhang, Yunpeng,Guo, Jing,Guo, Aike,&Li, Yan.(2016).Nicotine-induced acute hyperactivity is mediated by dopaminergic system in a sexually dimorphic manner.Neuroscience,332,149-159. |
| MLA | Zhang, Yunpeng,et al."Nicotine-induced acute hyperactivity is mediated by dopaminergic system in a sexually dimorphic manner".Neuroscience 332(2016):149-159. |
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来源：中国科学院大学
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