Identification of an adaptor protein that facilitates nrf2-keap1 complex formation and modulates antioxidant response
文献类型：期刊论文
| 作者 | Zhang, Yuxue1; Hou, Yongfan1; Liu, Chunchun1; Li, Yinlong2; Guo, Weiwei1; Wu, Jiu-Lin3; Xu, Daqian1; You, Xue1,4; Pan, Yi1; Chen, Yan1 |
| 刊名 | Free radical biology and medicine
 |
| 出版日期 | 2016-08-01 |
| 卷号 | 97页码:38-49 |
| 关键词 | Nrf2 Keap1 Antioxidant Ubiquitination Paqr3 Golgi apparatus |
| ISSN号 | 0891-5849 |
| DOI | 10.1016/j.freeradbiomed.2016.05.017 |
| 通讯作者 | Chen, yan(ychen3@sibs.ac.cn) |
| 英文摘要 | Nrf2 plays a key role in the protection of the body against environmental stress via inducible expression of detoxification and antioxidant enzymes. keapl functions as a sensor for oxidative and electrophilic stresses and promotes nrf2 degradation via its e3 ligase activity. modulation of the nrf2-keap1 pathway has been extensively explored as a strategy to combat against drug toxicity and stress-induced diseases. here we report a new player that modulates the nrf2-keap1 pathway. paqr3, a membrane protein specifically localized in the golgi apparatus, negatively regulates the expression of an array of nrf2 target genes and alters cellular level of reactive oxygen species. paqr3 tethers nrf2 and keapl, but not small maf proteins to the golgi apparatus. paqr3 interacts with both nrf2 and keapl and facilitates the interaction of nrf2 with keapl. paqr3 promotes ubiquitination and degradation of nrf2. disruption of paqr3 interaction with nrf2 and keapl by a synthetic peptide reduces nrf2 ubiquitination and elevates expression of nrf2 target genes. at the animal level, deletion of paqr3 increases nrf2 protein level and the expression of nrf2 target genes. in conclusion, our study pinpoints that paqr3 functions as an adaptor protein to promote nrf2-keap1 complex formation, thereby modulating the nrf2-keap2 pathway and playing an important role in controlling antioxidant response of the cell. (c) 2016 elsevier inc. all rights reserved. |
| WOS关键词 | PLACEBO-CONTROLLED PHASE-3 ; OXIDATIVE STRESS ; HEPATOCELLULAR-CARCINOMA ; TRANSCRIPTION FACTOR ; MULTIPLE-SCLEROSIS ; BARDOXOLONE METHYL ; TUMOR-SUPPRESSOR ; GOLGI-APPARATUS ; ORAL BG-12 ; NRF2 |
| WOS研究方向 | Biochemistry & Molecular Biology ; Endocrinology & Metabolism |
| WOS类目 | Biochemistry & Molecular Biology ; Endocrinology & Metabolism |
| 语种 | 英语 |
| WOS记录号 | WOS:000381924100004 |
| 出版者 | ELSEVIER SCIENCE INC |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2376342 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Chen, Yan |
| 作者单位 | 1.Univ Chinese Acad Sci, Shanghai Inst Biol Sci, Chinese Acad Sci, Key Lab Nutr & Metab,Inst Nutr Sci, Shanghai 200031, Peoples R China 2.Chinese Ctr Dis Control & Prevent, Natl Inst Parasit Dis, Shanghai 200336, Peoples R China 3.Fuzhou Univ, Inst Biomed & Pharmaceut Technol, Fuzhou 350002, Peoples R China 4.Shanghai Tech Univ, Sch Life Sci & Technol, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Yuxue,Hou, Yongfan,Liu, Chunchun,et al. Identification of an adaptor protein that facilitates nrf2-keap1 complex formation and modulates antioxidant response[J]. Free radical biology and medicine,2016,97:38-49. |
| APA | Zhang, Yuxue.,Hou, Yongfan.,Liu, Chunchun.,Li, Yinlong.,Guo, Weiwei.,...&Chen, Yan.(2016).Identification of an adaptor protein that facilitates nrf2-keap1 complex formation and modulates antioxidant response.Free radical biology and medicine,97,38-49. |
| MLA | Zhang, Yuxue,et al."Identification of an adaptor protein that facilitates nrf2-keap1 complex formation and modulates antioxidant response".Free radical biology and medicine 97(2016):38-49. |
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来源：中国科学院大学
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