Selective maturation of temporal dynamics of intracortical excitatory transmission at the critical period onset
文献类型：期刊论文
| 作者 | Miao, Qinglong1,2; Yao, Li1; Rasch, Malte J.1; Ye, Qian1; Li, Xiang1; Zhang, Xiaohui1 |
| 刊名 | Cell reports
 |
| 出版日期 | 2016-08-09 |
| 卷号 | 16期号:6页码:1677-1689 |
| ISSN号 | 2211-1247 |
| DOI | 10.1016/j.celrep.2016.07.013 |
| 通讯作者 | Zhang, xiaohui(xhzhang@bnu.edu.cn) |
| 英文摘要 | Although the developmental maturation of cortical inhibitory synapses is known to be a critical factor in gating the onset of critical period (cp) for experience-dependent cortical plasticity, how synaptic transmission dynamics of other cortical synapses are regulated during the transition to cp remains unknown. here, by systematically examining various intracortical synapses within layer 4 of the mouse visual cortex, we demonstrate that synaptic temporal dynamics of intracortical excitatory synapses on principal cells (pcs) and inhibitory parvalbuminor somatostatin-expressing cells are selectively regulated before the cp onset, whereas those of intracortical inhibitory synapses and long-range thalamocortical excitatory synapses remain unchanged. this selective maturation of synaptic dynamics results from a ubiquitous reduction of presynaptic release and is dependent on visual experience. these findings provide an additional essential circuit mechanism for regulating cp timing in the developing visual cortex. |
| WOS关键词 | PRIMARY VISUAL-CORTEX ; SHORT-TERM PLASTICITY ; EXPERIENCE-DEPENDENT PLASTICITY ; LAYER 4 ; INHIBITORY NEURONS ; GABAERGIC INTERNEURONS ; SYNAPTIC PLASTICITY ; SYNAPSES ; NEOCORTEX ; MOUSE |
| WOS研究方向 | Cell Biology |
| WOS类目 | Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000381373400018 |
| 出版者 | CELL PRESS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2376346 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Zhang, Xiaohui |
| 作者单位 | 1.Beijing Normal Univ, IDG McGovern Inst Brain Res, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China 2.Chinese Acad Sci, Univ Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Miao, Qinglong,Yao, Li,Rasch, Malte J.,et al. Selective maturation of temporal dynamics of intracortical excitatory transmission at the critical period onset[J]. Cell reports,2016,16(6):1677-1689. |
| APA | Miao, Qinglong,Yao, Li,Rasch, Malte J.,Ye, Qian,Li, Xiang,&Zhang, Xiaohui.(2016).Selective maturation of temporal dynamics of intracortical excitatory transmission at the critical period onset.Cell reports,16(6),1677-1689. |
| MLA | Miao, Qinglong,et al."Selective maturation of temporal dynamics of intracortical excitatory transmission at the critical period onset".Cell reports 16.6(2016):1677-1689. |
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来源：中国科学院大学
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