Mild prenatal stress exposure contributed to behavioral changes induced by postnatal injections and blocked the effects of olanzapine
文献类型：期刊论文
| 作者 | Shan Liang1,2; Liu Tian-E1; Zhao Xu-Dong1; Ma Yuan-Ye1 |
| 刊名 | Progress in biochemistry and biophysics
 |
| 出版日期 | 2015-06-01 |
| 卷号 | 42期号:6页码:543-550 |
| ISSN号 | 1000-3282 |
| 关键词 | Mild prenatal stress exposure Postnatal injection Olanzapine treatment Social discrimination test Olfactory discrimination test |
| 通讯作者 | Ma yuan-ye(yuanma0716@vip.sina.com) |
| 英文摘要 | Exposure of pregnant females to strong prenatal stress generally induces psychotic-like behavioral impairments in their offspring. in contrast to strong stress exposure, mild prenatal stress exposure (mpse) has been reported to increase the vulnerability of the nervous system to adverse environmental stimuli. however, the impacts of mpse on treatment with antipsychotic medication have not been well investigated. in addition, although commonly utilized in animal experiments, the potential influences of injections per se on animal behavior have not been evaluated. here, we investigated how mpse, postnatal injections and olanzapine (olz) treatment might interact to affect the behavior of rats. pregnant female rats were exposed to mild stress or left undisturbed during the last week of gestation. their offspring were divided into three sub-groups and subjected to injections with saline or olz (2 mg/kg) on postnatal days (pds) 7, 9 and 11 or were left undisturbed without injection. social and olfactory discrimination tests were performed during adolescent (pd 35) and adult (pd 60) periods. total exploratory time and the degree of preference in the discrimination tests were measured. we found that postnatal injections changed the degree of preference in adolescent prenatally stressed rats but had no effect on the degree of preference in the non-stressed rats. olz treatment increased the social exploratory time in the non-stressed rats during the adolescent and adult periods. however, these enhancing effects were diminished in the prenatally stressed rats. our results indicate that mpse could contribute to the behavioral changes induced by adverse stimuli such as postnatal injections and could reduce the treatment effects of antipsychotic medication. |
| WOS关键词 | PITUITARY-ADRENAL AXIS ; ADULT MALE RATS ; RECOGNITION MEMORY ; CONDITIONED FEAR ; SCHIZOPHRENIA ; HALOPERIDOL ; BRAIN ; VULNERABILITY ; RISPERIDONE ; EXTINCTION |
| WOS研究方向 | Biochemistry & Molecular Biology ; Biophysics |
| WOS类目 | Biochemistry & Molecular Biology ; Biophysics |
| 语种 | 英语 |
| 出版者 | CHINESE ACAD SCIENCES, INST BIOPHYSICS |
| WOS记录号 | WOS:000356911300007 |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2376391 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Ma Yuan-Ye |
| 作者单位 | 1.Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Shan Liang,Liu Tian-E,Zhao Xu-Dong,et al. Mild prenatal stress exposure contributed to behavioral changes induced by postnatal injections and blocked the effects of olanzapine[J]. Progress in biochemistry and biophysics,2015,42(6):543-550. |
| APA | Shan Liang,Liu Tian-E,Zhao Xu-Dong,&Ma Yuan-Ye.(2015).Mild prenatal stress exposure contributed to behavioral changes induced by postnatal injections and blocked the effects of olanzapine.Progress in biochemistry and biophysics,42(6),543-550. |
| MLA | Shan Liang,et al."Mild prenatal stress exposure contributed to behavioral changes induced by postnatal injections and blocked the effects of olanzapine".Progress in biochemistry and biophysics 42.6(2015):543-550. |
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来源：中国科学院大学
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